Results 71 to 80 of about 58,219 (300)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Interpreting OPERA results on superluminal neutrino

, 2011
OPERA has claimed the discovery of superluminal propagation of neutrinos. We analyze the consistency of this claim with previous tests of special relativity.
Adam, Adamson, Aguilar-Arevalo, Alekseev, Alessandro Strumia, Altschul, Altschul, Altschul, Amelino-Camelia, Bennett, Bionta, Blas, Bolokhov, Cacciapaglia, Carone, Cohen, Coleman, Csaki, Dent, Ellis, Ellis, Gian F. Giudice, Giudice, Groot Nibbelink, Hirata, Horava, Kalbfleisch, Kiritsis, Kostelecky, Kostelecky, Pas, Sergey Sibiryakov, Stecker, Strumia, Wess   +34 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Conservative, special-relativistic smoothed particle hydrodynamics

, 2010
We present and test a new, special-relativistic formulation of Smoothed Particle Hydrodynamics (SPH). Our approach benefits from several improvements with respect to earlier relativistic SPH formulations.
Anile, Anile, Anninos, Balsara, Benz, Celotti, Cha, Chow, Del Zanna, Dolag, Dolezal, Donat, Dubal, Eltgroth, Falle, Fock, Gallant, Gingold, Inutsuka, Kheyfets, Laguna, Liang, Lucy, Mann, Mann, Marquina, Marti, Marti, Marti, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Morris, Nelson, Norman, Piran, Press, Read, Rosswog, Rosswog, Rosswog, Rosswog, Siegler, Springel, Stephan Rosswog, Taub, Wen   +49 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Gravitational Lorentz Violation and Superluminality via AdS/CFT Duality

, 2008
A weak quantum mechanical coupling is constructed permitting superluminal communication within a preferred region of a gravitating AdS_5 spacetime. This is achieved by adding a spatially non-local perturbation of a special kind to the Hamiltonian of a ...
E. Witten, J. M. Maldacena, Raman Sundrum, S. Dubovsky   +3 more
core   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

On the possibility of measuring relativistic gravitational effects with a LAGEOS-LAGEOS II-OPTIS-mission

, 2002
In this paper we wish to preliminary investigate if it would be possible to use the orbital data from the proposed OPTIS mission together with those from the existing geodetic passive SLR LAGEOS and LAGEOS II satellites in order to perform precise ...
Ciufolini I, Ciufolini I, Ciufolini I, Ciufolini I, Claus Lämmerzahl, Dittus H Lämmerzahl C Peters A Schiller S, Eanes R J, Erricos C Pavlis, Everitt C W F, Hansjörg Dittus, Huang T, Ignazio Ciufolini, Iorio L, Iorio L, Iorio L Morea A, Lemoine F G, Lense J, Lockerbie N, Lorenzo Iorio, Lämmerzahl C, Lämmerzahl C, Maleki L, Mashhoon B, Nobili A M, Pavlis E C, Pound R V, Ries J C, Ries J C Eanes R J Tapley B D Peterson G E, Sanders A J, Schiff L I, Schäfer G, Stephan Schiller, Tapley B D Chambers D P Cheng M K Kim M C Poole S Ries J C, Touboul P, Turyshev S Shao M Nordvedt K, Turyshev S Williams J G Nordvedt K Shao M Murphy T W, Will C M   +36 more
core   +2 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source