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Safety and immunogenicity of an acellular pertussis vaccine containing genetically detoxified pertussis toxin administered to pregnant women living with and without HIV and their newborns (WoMANPOWER): a randomised controlled trial in Uganda.

open access: yesLancet Glob Health
Nakabembe E   +22 more
europepmc   +1 more source
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Molecular Pharmacology of Botulinum Toxin and Tetanus Toxin

Annual Review of Pharmacology and Toxicology, 1986
Botulinum toxin is a term that has been used to describe eight different substances designated types A, B, Cb C2, D, E, F, and G. For many years it was assumed that these eight substances acted at the neuromuscular junction to block acetylcholine release. It is now known that this assumption is not entirely correct.
L. Simpson
openaire   +4 more sources

Studies on tetanus toxin [PDF]

open access: possibleActa Neuropathologica, 1964
In a series ofin vivo andin vitro experiments employing crude and purified tetanus toxin labelled with fluorescent dyes, the following observations were made:
Sumner I. Zacks, Michael F. Sheff
openaire   +2 more sources

On the structure of tetanus toxin

Naunyn-Schmiedeberg's Archives of Pharmacology, 1973
Previous results from the literature pertaining to the molecular state of tetanus toxin are reported. By use of disc electrophoresis, gel filtration and ultracentrifugation, it is shown in this paper that tetanus toxin is likely to be constituted of subunits.
Bernard Bizzini   +2 more
openaire   +3 more sources

Tetanus toxin conformation

Molecular and Cellular Biochemistry, 1974
The circular dichroic spectrum of highly purified tetanus toxin has been determined between 200–310 nm. A comparison of the ellipticity between 207–243 nm and of the rotational strengths of the major resolved bands between 200–250 nm with the corresponding values from proteins of known conformation indicates that tetanus toxin contains about 20% α ...
John B. Picklesimer   +3 more
openaire   +3 more sources

Immunochemistry of Tetanus Toxin

European Journal of Biochemistry, 1973
The tyrosyl residues of tetanus toxin can be specifically nitrated by tetranitromethane. The introduction of NO2 groups into the toxin molecule is followed by a rapid decrease in toxicity. Although tryptophyl residues are differently involved and some aggregation occurs, these two phenomena do not take any significant part in the toxicity loss.
Turpin A   +2 more
openaire   +3 more sources

Diphtheria-tetanus-pertussis vaccine: past, current & future.

Future Microbiology, 2021
The diphtheria-tetanus-pertussis (DTP) vaccine can prevent diphtheria, tetanus and pertussis. The component antigens of the DTP vaccine had long been monovalent vaccines. The pertussis vaccine was licensed in 1914.
Marta Prygiel   +3 more
semanticscholar   +1 more source

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