Results 201 to 210 of about 16,250 (289)

Multi‐Omic Assessment of Microbial Communities and Their Polyketide Biosynthetic Potential Across Abyssal Sediments

open access: yesEnvironmental Microbiology, Volume 28, Issue 5, May 2026.
Abyssal sediments were assessed for taxonomic diversity and polyketide biosynthetic potential and compared to metagenomic and metabolomic assessments of the same sediments. Biodiversity differences were documented across biogeochemical regimes with the results providing baseline awareness of what might be lost should deep‐sea microbiomes be disrupted ...
Hans W. Singh   +7 more
wiley   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 10, Page 2518-2532, May 2026.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki   +4 more
wiley   +1 more source

The Neuromuscular Junction Distribution in the Upper Face: An Anatomy‐to‐Practice Review to Inform Botulinum Toxin Type A Treatment Planning

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background Upper‐face botulinum toxin treatment planning often relies on surface landmarks and standardized injection patterns, yet neuromuscular junctions are distributed in muscle‐specific motor zones that vary in topography, depth, and overlap. Injecting near an optimal motor zone has been associated with greater clinical effect, suggesting
Fabiano Nadson Magacho‐Vieira
wiley   +1 more source

Phototriggered Morphological and Compositional Change of UGGAA Repeat RNA Foci by Photoswitchable RNA‐Binding Ligand

open access: yesAngewandte Chemie, Volume 138, Issue 18, 27 April 2026.
We here developed a molecular tool for the optical control of UGGAA repeat RNA foci, a pathological hallmark of spinocerebellar ataxia type 31 (SCA31). The photoswitchable RNA‐binding ligand enabled reversible control of the RNA foci. UV irradiation induced the growth of the RNA foci, while subsequent visible light irradiation dissolved the structure ...
Yusuke Fujiwara   +2 more
wiley   +2 more sources

Tau condensation on DNA mediates microtubule attachment suggesting a mitotic role for centromere-localized tau. [PDF]

open access: yesNat Commun
Park C   +18 more
europepmc   +1 more source

Synergistic Effects of Endolift With Complementary Cosmetic Procedures: A Narrative Review and Comprehensive Approach

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background The landscape of aesthetic medicine has increasingly favored minimally invasive interventions, with the 1470 nm diode laser (Endolift) gaining prominence as a viable alternative to surgical lifting for soft‐tissue remodeling and lipolysis. Aims This narrative review synthesizes current evidence on the mechanism, clinical versatility,
Mohammad Ali Nilforoushzadeh   +4 more
wiley   +1 more source

Quantifying Under‐Ice Phytoplankton Blooms in the Changing Arctic and Southern Oceans

open access: yesGeophysical Research Letters, Volume 53, Issue 8, 28 April 2026.
Abstract Historically, polar marine phytoplankton were thought to primarily grow after the seasonal breakup of sea ice, when there is plentiful light available in the surface ocean. However, observations of substantial productivity under sea ice has called this assumption into question.
Courtney M. Payne   +4 more
wiley   +1 more source

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