Results 31 to 40 of about 6,311 (195)

Viabilidade de sementes armazenadas de Himatanthus sucuuba Wood pelo teste de tetrazólio

, 2021
Himatanthus sucuuba is an Amazonian tree species of importance in traditional medicine because of its therapeutic properties. Estimates of seed viability are still scarce, so it is necessary to develop rapid tests to evaluate seed quality. The objectives
L. H. Sáenz-Ramírez, Angela Maria da Silva Mendes, Angela Maria Imakawa, P. D. T. B. Sampaio, Maria da Glória Gonçalves de Melo   +4 more
semanticscholar   +1 more source

FOXM1 Inhibition Enhances the Therapeutic Outcome of Lung Cancer Immunotherapy by Modulating PD‐L1 Expression and Cell Proliferation

Advanced Science, Volume 9, Issue 29, October 14, 2022., 2022
In this study, the authors show that FOXM1 selectively regulates PD‐L1 expression by binding directly to the PD‐L1 promoter. The FOXM1 inhibitor significantly lowers PD‐L1 levels and tumor growth in vitro and in vivo without any side effects on vital normal tissues.
Hamadi Madhi, Jeon‐Soo Lee, Young Eun Choi, Yan Li, Myoung Hee Kim, Yongdoo Choi, Sung‐Ho Goh   +6 more
wiley   +1 more source

Development of a potent small‐molecule degrader against oncogenic BRAFV600E protein that evades paradoxical MAPK activation

Cancer Science, Volume 113, Issue 8, Page 2828-2838, August 2022., 2022
In this study, we developed chimeric compounds, proteolysis targeting chimeras (PROTACs), that target BRAF V600E protein for degradation. CRBN(BRAF)‐24, the most effective chimera, selectively degraded BRAF V600E in a ubiquitin‐proteasome system (UPS)‐dependent manner and inhibited the proliferation of BRAF V600E‐driven cancer cells.
Nobumichi Ohoka, Masanori Suzuki, Takuya Uchida, Yoshinori Tsukumo, Masayuki Yoshida, Takao Inoue, Hitoshi Ohki, Mikihiko Naito   +7 more
wiley   +1 more source

Baseline and time‐updated factors in preclinical development of anionic dendrimers as successful anti‐HIV‐1 vaginal microbicides

WIREs Nanomedicine and Nanobiotechnology, Volume 14, Issue 3, May/June 2022., 2022
Key preclinical steps in the development of a vaginal microbicide against HIV‐1 infection to lead to clinical trials. Abstract Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy, most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 (HIV‐1) in human clinical trials.
Ignacio Rodríguez‐Izquierdo, Daniel Sepúlveda‐Crespo, Jose María Lasso, Salvador Resino, Ma Ángeles Muñoz‐Fernández   +4 more
wiley   +1 more source

Identification of natural compounds tubercidin and lycorine HCl against small‐cell lung cancer and BCAT1 as a therapeutic target

Journal of Cellular and Molecular Medicine, Volume 26, Issue 9, Page 2557-2565, May 2022., 2022
Abstract Although small‐cell lung cancer (SCLC) accounts for a small fraction of lung cancer cases (~15%), the prognosis of patients with SCLC is poor with an average overall survival period of a few months without treatment. Current treatments include standard chemotherapy, which has minimal efficacy and a newly developed immunotherapy that thus far ...
Jungang Chen, Lindsey Barrett, Zhen Lin, Samantha Kendrick, Shengyu Mu, Lu Dai, Zhiqiang Qin   +6 more
wiley   +1 more source

AVALIAÇÃO DA QUALIDADE FISIOLÓGICA DE SEMENTES DE CANELA-PRETA (Ocotea catharinensis Mez-LAURACEAE) PELA CULTURA in vitro DE EIXOS EMBRIONÁRIOS E PELO TESTE DE TETRAZÓLIO

Revista do Instituto Florestal, 1998
Objetivando avaliar com rapidez a qualidade fisiológica das sementes de Ocotea catharinensis (canela-preta), foram aplicadas técnicas de desenvolvimento in vitro de eixos embrionários e do teste bioquímico de viabilidade.
Antonio da Silva, lvor Bergemann de Aguiar   +1 more
doaj   +1 more source

Temperatura e pré-condicionamento de sementes de soja para o teste de tetrazólio Temperature and preconditioning of soybean seeds for the tetrazolium test on soybean seeds

Scientia Agricola, 1994
Com o objetivo de encontrar uma alternativa metodológica para a redução do período de condicionamento (tempo de embebição) que antecede o processo de coloração de sementes para a realização do teste de tetrazólio, foram estudados quatro períodos de ...
N.P. da Costa, J. Marcos Filho
doaj   +1 more source

Optimización de la prueba de tetrazolio para evaluar la viabilidad en semillas de Solanum lycopersicum L.

, 2020
Tomato (Solanum lycopersicum) is one of the most consumed vegetables worldwide with increasing demand. erefore, knowing its seeds viability is of utmost importance since these are the basis of their production success.
Seir Antonio Salazar Mercado, Edinson Alexander Botello Delgado, Jesús David Quintero Caleño   +2 more
semanticscholar   +1 more source

Implementación de la prueba de tetrazolio en las semillas de Raphanus sativus L

, 2020
Radish (Raphanus Sativus) is a significant species due to its nutritional properties, the high oil percentage of its seeds and the large number of usable metabolites.
Seir Antonio Salazar Mercado, Jesús David Quintero Caleño, Víctor Jhoel Bustos Urbano   +2 more
semanticscholar   +1 more source

Adaptation of the tetrazolium test for evaluation of Ceiba speciosa seeds
Adequação do teste de tetrazólio para avaliação da qualidade de sementes de Ceiba speciosa

Semina: Ciências Agrárias, 2011
The objective of this research was to define the tetrazolium test methodology for Ceiba speciosa seeds. Two C. speciosa seeds samples were used and, for each of these, it were determinate the moisture content and germination.
Lia Rejane Silveira Reiniger, Marlove Fátima Brião Muniz, Graziela Piveta, Marília Lazarotto   +3 more
doaj   +1 more source