Results 21 to 30 of about 15,280 (202)

Prehabilitation Prior to Colorectal Cancer Surgery: Impact and Implementation. [PDF]

J Surg Oncol
ABSTRACT Background and Objectives Multimodal prehabilitation aims to improve surgical outcomes and preoperative fitness in patients undergoing surgery for colorectal cancer (CRC). This study evaluated implementation of a standardised prehabilitation programme for elective CRC surgery, assess its impact, and identify pitfalls and challenges during ...
Lockhorst EW, Backhuijs TAM, Kerkhoff TME, van den Braak RRJC, Ayez N, Verhoef C, Gobardhan PD, Schreinemakers JMJ.   +7 more
europepmc   +2 more sources

The Art of Life: An Ancient Idea and Its Survival [PDF]

SCHOLE, 2008
Teun Tieleman (UCLA / Utrecht University) surveys the history of the philosophical notion of the ‘art of life’, starting from its originator Socrates and his ancient successors down to its role among present-day philosophers. Apart from Socrates, special
Tieleman, Teun
doaj   +1 more source

RRAGD p.(Ser76Leu) Variant Causes Dysregulated Expression of Muscle Development and Cytoskeleton Genes in Cardiomyocytes. [PDF]

FASEB J
Under normal conditions, RagD and mTORC1 respond to amino acid changes. Upon stimulation, active mTORC1 phosphorylates S6K, 4E‐BP1, and TFEB. In response to starvation, mTORC1 is inactive. Our data indicate that the RRAGD p.(Ser76Leu) variant maintains the phosphorylation of mTORC1 targets during starvation in T‐REx HeLa cells.
Adella A, van Katwijk SB, Leermakers PA, van Ham WB, de Ruiter H, Ilgutytė J, Hendrickx S, Nijland L, de Boer TP, van Rooij E, Hoenderop JGJ, de Baaij JHF.   +11 more
europepmc   +2 more sources

The Negative Impact of a Non-Therapeutic Laparotomy in Patients With Inoperable Colorectal Peritoneal Metastases. [PDF]

J Surg Oncol
ABSTRACT Background The peritoneum is the third most prevalent location for metastases of colorectal cancer. In patients with resectable disease, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC) is the preferred treatment in the Netherlands, achieving median overall survival (OS) of 36–42 months. However, during
Heuvel TVD, Kesteren LV, Nienhuijs S, Burger P, Buffart T, Tuynman J, Hingh I.   +6 more
europepmc   +2 more sources

Simulation Framework to Investigate Efficacy and Ocular Safety of Belantamab Mafodotin Combinations in Relapsed/Refractory Multiple Myeloma. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Quantitative modeling can guide drug development and regulatory decisions by providing insights into pharmacokinetics, pharmacodynamics, efficacy, and safety. Integrating models allows simulations that support dosing considerations. A simulation framework for belantamab mafodotin (B) in relapsed/refractory multiple myeloma was developed using ...
Carreño F, van Noort M, Taylor A, Zeiser S, Papathanasiou T, Post TM, Lien YTK, Ho YL, Ferron-Brady G.   +8 more
europepmc   +2 more sources

Inside-Out Approach of Lumbar Endoscopic Unilateral Laminotomy for Bilateral Decompression: A Detailed Technical Description, Rationale and Outcomes [PDF]

Neurospine, 2020
Although lumbar stenosis was recognized as a contraindication for endoscopic spine surgery in the past, the advancement in endoscopic system design and development of approach techniques and strategies now enabled the endoscopic spine surgeons to manage ...
Kang Taek Lim, Elmer Jose Arevalo Meceda, Chun-Kun Park   +2 more
doaj   +1 more source

Single-Molecule Imaging and Spectroscopy Enables Quantification of Location-Dependent Light-Matter Interactions on Nanoantennas. [PDF]

Small Sci
The fluorescence intensity as well as the spectral shape of the emission of single dye molecules strongly depend on the molecules’ exact position relative to plasmonic nanoparticles in hybrid systems. By point‐spread function modification analysis, the vertical binding location of single fluorophores on gold nanocones is obtained and correlated to both
Lang L, Nooteboom S, Huijben TAPM, Mahajan S, Marie R, Zijlstra P, Fleischer M.   +6 more
europepmc   +2 more sources

SOCIEDAD Y DISCURSO Teun A. Van Dijk [PDF]

Literatura Y Linguistica, 2013
exaly   +4 more sources

Percutaneous Stenoscopic Lumbar Decompression with Paramedian Approach for Foraminal/Extraforaminal Lesions [PDF]

Asian Spine Journal, 2019
The lumbar foramen is affected by different degenerative diseases, including extraforaminal disc herniation, foraminal stenosis (FS), and degenerative or spondylolytic spondylolisthesis.
Han Ga Wi Nam, Hyung Suk Kim, Dong Keun Lee, Chun-Kun Park, Kang Taek Lim   +4 more
doaj   +1 more source

Therapeutic Feasibility of Full Endoscopic Decompression in One- to Three-Level Lumbar Canal Stenosis via a Single Skin Port Using a New Endoscopic System, Percutaneous Stenoscopic Lumbar Decompression [PDF]

Asian Spine Journal, 2019
Study Design This retrospective study involved 450 consecutive cases of degenerative lumbar stenosis treated with percutaneous stenoscopic lumbar decompression (PSLD).
Kang Taek Lim, Han Ga Wi Nam, Soo Beom Kim, Hyung Suk Kim, Jin Soo Park, Chun-Kun Park   +5 more
doaj   +1 more source