Results 11 to 20 of about 2,619 (131)

RRAGD p.(Ser76Leu) Variant Causes Dysregulated Expression of Muscle Development and Cytoskeleton Genes in Cardiomyocytes. [PDF]

FASEB J
Under normal conditions, RagD and mTORC1 respond to amino acid changes. Upon stimulation, active mTORC1 phosphorylates S6K, 4E‐BP1, and TFEB. In response to starvation, mTORC1 is inactive. Our data indicate that the RRAGD p.(Ser76Leu) variant maintains the phosphorylation of mTORC1 targets during starvation in T‐REx HeLa cells.
Adella A, van Katwijk SB, Leermakers PA, van Ham WB, de Ruiter H, Ilgutytė J, Hendrickx S, Nijland L, de Boer TP, van Rooij E, Hoenderop JGJ, de Baaij JHF.   +11 more
europepmc   +2 more sources

Simulation Framework to Investigate Efficacy and Ocular Safety of Belantamab Mafodotin Combinations in Relapsed/Refractory Multiple Myeloma. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Quantitative modeling can guide drug development and regulatory decisions by providing insights into pharmacokinetics, pharmacodynamics, efficacy, and safety. Integrating models allows simulations that support dosing considerations. A simulation framework for belantamab mafodotin (B) in relapsed/refractory multiple myeloma was developed using ...
Carreño F, van Noort M, Taylor A, Zeiser S, Papathanasiou T, Post TM, Lien YTK, Ho YL, Ferron-Brady G.   +8 more
europepmc   +2 more sources

Single-Molecule Imaging and Spectroscopy Enables Quantification of Location-Dependent Light-Matter Interactions on Nanoantennas. [PDF]

Small Sci
The fluorescence intensity as well as the spectral shape of the emission of single dye molecules strongly depend on the molecules’ exact position relative to plasmonic nanoparticles in hybrid systems. By point‐spread function modification analysis, the vertical binding location of single fluorophores on gold nanocones is obtained and correlated to both
Lang L, Nooteboom S, Huijben TAPM, Mahajan S, Marie R, Zijlstra P, Fleischer M.   +6 more
europepmc   +2 more sources

Similar Individual Serum Levels of MCP-1, TNF-α, and IL-6 From Periodontitis Patients Before and 1 Year After Treatment. [PDF]

Scand J Immunol
Periodontitis patients before and 1 year present with similar levels of MCP‐1, TNF‐α, and IL‐6, cytokine equilibrium. MCP‐1, TNF‐α, and IL‐6 are not correlated per individual, meaning that some individuals may present with relatively high levels of one of the cytokines with lower levels of the other cytokines or cytokine signature.
de Vries TJ, Bizzarro S, Di Ceglie I, Sol DY, van Lent PLEM, Schoenmaker T.   +5 more
europepmc   +2 more sources

Cell-f identity of biomedical students: from energetic “mitochondrials” to gastronomic “lysosomics” [PDF]

Frontiers in Medicine
At the start of a Molecular Cell Biology course, 66 students from the biomedical track introduced themselves by identifying with a specific cell component. On the final exam, they were asked once again to name their favorite cell component at that moment—
Teun J. de Vries, Teun J. de Vries
doaj   +2 more sources

Reliability and Radiographic Correlation of the Foot Posture Index-6: A Multi-Rater Analysis in Symptomatic and Asymptomatic Individuals [PDF]

Diagnostics
Background/Objectives: The foot posture index (FPI-6) is a practical clinical tool for evaluating standing foot posture using six specific criteria. Although widely used, its reliability and correlation with radiographic parameters remain uncertain. This
Min Gyu Kyung, Yun Jae Cho, Jae Hee Lee, Min Seok Shin, Jay Hoon Park, Dong Yeon Lee   +5 more
doaj   +2 more sources

Model-Informed Drug Development for Daprodustat Supports the Design of Individualized Dosing Regimens in Chronic Kidney Disease Patients With Anemia. [PDF]

Clin Pharmacol Ther
Model‐informed drug development (MIDD) played a crucial role in the successful development and regulatory approval of daprodustat, a novel oral hypoxia‐inducible factor prolyl hydroxylase (HIF‐PHI) inhibitor aimed at treating anemia in chronic kidney disease patients.
Mahar KM, Yang S, Johnson B, Visser SAG, van den Berg P, van den Berg P, van Noort M, Post TM.   +7 more
europepmc   +2 more sources

Inside-Out Approach of Lumbar Endoscopic Unilateral Laminotomy for Bilateral Decompression: A Detailed Technical Description, Rationale and Outcomes [PDF]

Neurospine, 2020
Although lumbar stenosis was recognized as a contraindication for endoscopic spine surgery in the past, the advancement in endoscopic system design and development of approach techniques and strategies now enabled the endoscopic spine surgeons to manage ...
Kang Taek Lim, Elmer Jose Arevalo Meceda, Chun-Kun Park   +2 more
doaj   +1 more source

Percutaneous Stenoscopic Lumbar Decompression with Paramedian Approach for Foraminal/Extraforaminal Lesions [PDF]

Asian Spine Journal, 2019
The lumbar foramen is affected by different degenerative diseases, including extraforaminal disc herniation, foraminal stenosis (FS), and degenerative or spondylolytic spondylolisthesis.
Han Ga Wi Nam, Hyung Suk Kim, Dong Keun Lee, Chun-Kun Park, Kang Taek Lim   +4 more
doaj   +1 more source

Therapeutic Feasibility of Full Endoscopic Decompression in One- to Three-Level Lumbar Canal Stenosis via a Single Skin Port Using a New Endoscopic System, Percutaneous Stenoscopic Lumbar Decompression [PDF]

Asian Spine Journal, 2019
Study Design This retrospective study involved 450 consecutive cases of degenerative lumbar stenosis treated with percutaneous stenoscopic lumbar decompression (PSLD).
Kang Taek Lim, Han Ga Wi Nam, Soo Beom Kim, Hyung Suk Kim, Jin Soo Park, Chun-Kun Park   +5 more
doaj   +1 more source