Prehabilitation Prior to Colorectal Cancer Surgery: Impact and Implementation. [PDF]
J Surg OncolABSTRACT Background and Objectives Multimodal prehabilitation aims to improve surgical outcomes and preoperative fitness in patients undergoing surgery for colorectal cancer (CRC). This study evaluated implementation of a standardised prehabilitation programme for elective CRC surgery, assess its impact, and identify pitfalls and challenges during ...
Lockhorst EW +7 more
europepmc +2 more sources
RRAGD p.(Ser76Leu) Variant Causes Dysregulated Expression of Muscle Development and Cytoskeleton Genes in Cardiomyocytes. [PDF]
FASEB JUnder normal conditions, RagD and mTORC1 respond to amino acid changes. Upon stimulation, active mTORC1 phosphorylates S6K, 4E‐BP1, and TFEB. In response to starvation, mTORC1 is inactive. Our data indicate that the RRAGD p.(Ser76Leu) variant maintains the phosphorylation of mTORC1 targets during starvation in T‐REx HeLa cells.
Adella A +11 more
europepmc +2 more sources
The Negative Impact of a Non-Therapeutic Laparotomy in Patients With Inoperable Colorectal Peritoneal Metastases. [PDF]
J Surg OncolABSTRACT Background The peritoneum is the third most prevalent location for metastases of colorectal cancer. In patients with resectable disease, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC) is the preferred treatment in the Netherlands, achieving median overall survival (OS) of 36–42 months. However, during
Heuvel TVD +6 more
europepmc +2 more sources
Inside-Out Approach of Lumbar Endoscopic Unilateral Laminotomy for Bilateral Decompression: A Detailed Technical Description, Rationale and Outcomes [PDF]
Neurospine, 2020 Although lumbar stenosis was recognized as a contraindication for endoscopic spine surgery in the past, the advancement in endoscopic system design and development of approach techniques and strategies now enabled the endoscopic spine surgeons to manage ...
Kang Taek Lim +2 more
doaj +1 more source
Simulation Framework to Investigate Efficacy and Ocular Safety of Belantamab Mafodotin Combinations in Relapsed/Refractory Multiple Myeloma. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Quantitative modeling can guide drug development and regulatory decisions by providing insights into pharmacokinetics, pharmacodynamics, efficacy, and safety. Integrating models allows simulations that support dosing considerations. A simulation framework for belantamab mafodotin (B) in relapsed/refractory multiple myeloma was developed using ...
Carreño F +8 more
europepmc +2 more sources
Percutaneous Stenoscopic Lumbar Decompression with Paramedian Approach for Foraminal/Extraforaminal Lesions [PDF]
Asian Spine Journal, 2019 The lumbar foramen is affected by different degenerative diseases, including extraforaminal disc herniation, foraminal stenosis (FS), and degenerative or spondylolytic spondylolisthesis.
Han Ga Wi Nam +4 more
doaj +1 more source
Therapeutic Feasibility of Full Endoscopic Decompression in One- to Three-Level Lumbar Canal Stenosis via a Single Skin Port Using a New Endoscopic System, Percutaneous Stenoscopic Lumbar Decompression [PDF]
Asian Spine Journal, 2019 Study Design This retrospective study involved 450 consecutive cases of degenerative lumbar stenosis treated with percutaneous stenoscopic lumbar decompression (PSLD).
Kang Taek Lim +5 more
doaj +1 more source
Minimally Invasive Spine Surgery in Korea - A Neurosurgeon’s View - [PDF]
Journal of Minimally Invasive Spine Surgery and Technique, 2016 In Korea, neurosurgery has taken the lead in minimally invasive spine surgery (MISS) since early 1980s, unlike most of other countries, in which orthopedic surgery usually leads MISS.
Chun-Kun Park
doaj +1 more source
Critical Discourse Analysis of Rejecting the Andesite Mining in Wadas Village News on Tempo.co
MediaTor, 2022 This study explains the dimension of the Teun A van Dijk model in online text news entitled "Rejecting the Andesite Mining in Wadas Village" by Tempo.co.
Abdi Sri Kuncoro
doaj +1 more source
Are Controversial Issues in Cervical Total Disc Replacement Resolved or Unresolved?: A Review of Literature and Recent Updates [PDF]
Asian Spine Journal, 2018 Since the launch of cervical total disc replacement (CTDR) in the early 2000s, many clinical studies have reported better outcomes of CTDR compared to those of anterior cervical discectomy and fusion. However, CTDR is still a new and innovative procedure
Chun-Kun Park, Kyeong-Sik Ryu
doaj +1 more source