Results 21 to 30 of about 55,878,904 (208)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Co-localization between placental CS and SDC1 in third-trimester placental tissue.
, 2016 (A) Co-localization analysis by PLA between placental CS (FV2 stain) and syndecan-1 (SDC1) on paraffin-embedded placental tissue perfused with VAR2CSA-expressing parasites showing the Co-localization of SDC1 and placental CS chains in the ...
Thor G. Theander (103961) +14 more
core +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Co-localization of p33 replication protein with Ufe1 and Use1 SNARE proteins.
, 2018 (A) Confocal laser microscopy analysis of subcellular distribution of GFP-tagged p33 and RFP-Ufe1 in wt yeast cells. Images were taken at two time points (as shown). Single frames are presented.
Paulina Alatriste Gonzalez (5205044) +4 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Image co-localization – co-occurrence versus correlation
, 2018 Fluorescence image co-localization analysis is widely utilized to suggest biomolecular interaction. However, there exists some confusion as to its correct implementation and interpretation.
Aaron B. Taylor +2 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
2. FID / Text+ Jour Fixe am 17. Mai
, 2023 Am 17.05.2023 findet auf Zoom von 9.00 bis 12.30 Uhr der 2. FID / Text+ Jour Fixe statt. Das im halbjährlichen Turnus veranstaltete Format zielt speziell auf die Zusammenarbeit zwischen Fachinformationsdiensten und Konsortium ab und möchte einen ...
Text+ Blog-Redaktion
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source