Results 41 to 50 of about 31,201,158 (317)

Den Blick für die jeweilige Gelegenheit öffnen

, 2023
Autor:innen: Barbara K. Fischer und Stefan Buddenbohm Ende November kamen gut 20 Mitarbeiter:innen aus unterschiedlichen Projekten mit GND-Bezug, wie NFDI-Konsortien, GND4C und GND-Redaktionen, im Arbeitskreis GND Community Empowerment zu ihrem dritten
Text+ Mitglied
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

CRFVoter: gene and protein related object recognition using a conglomerate of CRF-based tools

Journal of Cheminformatics, 2019
Background Gene and protein related objects are an important class of entities in biomedical research, whose identification and extraction from scientific articles is attracting increasing interest.
Wahed Hemati, Alexander Mehler
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Text+Plus, #02: DLA Data+, oder: Marbach goes Text+

, 2023
#02: DLA Data+ Jedes Jahr fördert Text+ Kooperationsprojekte mit einer Laufzeit von maximal 12 Monaten. Bewerben können sich Einzelpersonen, Arbeitsgruppen, Forschungsverbünde und Forschungseinrichtungen.
Karin Schmidgall
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Defects and defect-mediated engineering of two-dimensional materials: challenges and open questions

Beilstein Journal of Nanotechnology
Compared to bulk solids, defects in low-dimensional materials and, specifically, 2D systems are expected to have a stronger effect, detrimental or beneficial, on their properties.
Arkady V. Krasheninnikov, Matthias Batzill, Anouar-Akacha Delenda, Marija Drndić, Chris Ewels, Katharina J. Franke, Mahdi Ghorbani-Asl, Alexander Holleitner, Ado Jorio, Ute Kaiser, Daria Kieczka, Hannu-Pekka Komsa, Jani Kotakoski, Manuel Längle, David Lamprecht, Yun Liu, Steven G. Louie, Janina Maultzsch, Thomas Michely, Katherine Milton, Anna Niggas, Hanako Okuno, Joshua A. Robinson, Marika Schleberger, Bruno Schuler, Alexander Shluger, Kazu Suenaga, Kristian S. Thygesen, Richard A. Wilhelm, E. Harriet Åhlgren, Carla Bittencourt   +30 more
doaj   +1 more source