Results 31 to 40 of about 209,110 (252)

Impact of Japan's 2024 Physician Work‐Style Reform on Pediatric Hematology–Oncology: Educational Implications in a 2‐Year Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Japan's 2024 physician work‐style reform introduced legally binding limits on physicians’ working hours, but its impact on education and workforce sustainability in pediatric hematology–oncology (PHO) remains unclear. Procedure We conducted a repeated cross‐sectional study with structured quantitative items and free‐text responses ...
Kiyohiko Kaizu, Masaharu Akiyama, Toshikazu Itabashi, Jun Hayakawa, Takahiro Kikuchi, Ryohei Fukunaga, Katsuyoshi Koh, Takahiro Ueda   +7 more
wiley   +1 more source

Effectiveness of a smartphone app on improving immunization of children in rural Sichuan Province, China: a cluster randomized controlled trial

BMC Public Health, 2016
Background The aim of this study was to assess the effectiveness of an EPI smartphone application (EPI app) on improving vaccination coverage in rural Sichuan Province, China.
Li Chen, Xiaozhen Du, Lin Zhang, Michelle Helena van Velthoven, Qiong Wu, Ruikan Yang, Ying Cao, Wei Wang, Lihui Xie, Xiuqin Rao, Yanfeng Zhang, Jeanne Catherine Koepsell   +11 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Is health warning label compliance a country or manufacturer issue: a 9-country multi-year study

Tobacco Induced Diseases, 2018
Background Two agents are responsible for producing effective cigarette health warning labels (HWLs): governments ensure HWL legislation is comprehensive with clear implementing rules, and tobacco companies are responsible for implementation.
Michael Iacobelli, Kevin Welding, Carmen Washington, Katherine Smith, Joanna Cohen   +4 more
doaj   +1 more source

A Short Text Classification Method Based on Convolutional Neural Network and Semantic Extension

International Journal of Computational Intelligence Systems, 2020
In order to solve the problem that traditional short text classification methods do not perform well on short text due to the data sparsity and insufficient semantic features, we propose a short text classification method based on convolutional neural ...
Haitao Wang, Keke Tian, Zhengjiang Wu, Lei Wang   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Relationship between Iranian EFL Learners' Reading Comprehension, Vocabulary Size and Lexical Coverage of the Text: The Case of Narrative and Argumentative Genres [PDF]

Journal of English Language Pedagogy and Practice, 2017
This study explored the relationship between EFL learners’ vocabulary size, lexical coverage of the text and reading comprehension texts (narrative & argumentative genres).
Nader Assadi Aidinlou, Mitra Taghinezhad Vaskehmahalleh   +1 more
doaj  

Estimation of vaccine efficacy and critical vaccination coverage in partially observed outbreaks. [PDF]

PLoS Computational Biology, 2013
Classical approaches to estimate vaccine efficacy are based on the assumption that a person's risk of infection does not depend on the infection status of others. This assumption is untenable for infectious disease data where such dependencies abound. We
Michiel van Boven, Wilhelmina L M Ruijs, Jacco Wallinga, Philip D O'Neill, Susan Hahné   +4 more
doaj   +1 more source