Results 51 to 60 of about 1,103,913 (306)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Revista Brasileira de Linguística Aplicada, 2011 Tendo como base teórica os estudos sobre os gêneros discursivos e a teoria da atividade, este texto aborda questões relativas ao uso do livro didático (LD) de Língua Portuguesa. Verificamos a relação entre os agentes escolares e esse instrumento, focando
Dulce Cassol Tagliani
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
“You Know, I Could Trip and Fall Onto the Track!”: Inspiring Text Production
, 2019 The authors present the literacy pedagogical approach LAUNCH and reveal its influence on young learners as engineers of literacy learning through text production.
Michelle Neumann +5 more
core +1 more source
Pauses as indicators of cognitive effort in post-editing machine translation output [PDF]
, 2006 In translation process and language production research, pauses are seen as indicators of cognitive processing. Investigating the correlations between source text machine translatability and post-editing effort involves an assessment of cognitive effort.
O'Brien, Sharon, O\u27Brien, Sharon
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Text analysis and reader interaction [PDF]
, 1992 EFL teachers from the Brazilian public sector have often experienced difficulties in efficiently accessing the relevant information from articles published in 'English Teaching Forum'. This study attempts to investigate these difficulties from both 'text-
TEFL methods articles,
core
Coordinating sentence composition with error correction: A multilevel analysis
Journal of Writing Research, 2011 Error analysis involves detecting and correcting discrepancies between the 'text produced so far' (TPSF) and the writer's mental representation of what the text should be.
Van Waes, L., De Maeyer, S., Leijten, M.
doaj
The Effects of Manuscript, Cursive or Manuscript/Cursive Styles on Writing Development in Grade 2
Language and Literacy: A Canadian Educational e-journal, 2012 In the research area of writing development, an increasing number of researchers suggest that graphomotor skills could be much more important than they appear to be (Christensen, 2009).
Marie-France Morin +2 more
doaj +1 more source