Results 11 to 20 of about 425,602 (225)

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients. [PDF]

Br J Clin Pharmacol
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Laffitte Redondo C, Bourdin V, Ait Tayeb AEK, Benaboud S, Martins I, Joyau C, Benhamida M, Sermet-Gaudelus I, Martin C, Burgel PR, Verstuyft C, Chouchana L, Ayme-Dietrich E.   +12 more
europepmc   +2 more sources

CFTR Modulator Therapy and Aerobic Fitness Changes in Aerobic Fitness Following Initiation of CFTR Modulator Therapy: A Systematic Review and Meta-Analysis. [PDF]

Pediatr Pulmonol
ABSTRACT Introduction Cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy has led to relevant clinical advances in people with cystic fibrosis (pwCF). However, its effects on aerobic fitness are unclear. Objective To evaluate the effects of CFTR modulator therapy on aerobic fitness in pwCF through a systematic review and meta ...
de Almeida IS, Vendrusculo FM, da Costa MS, Donadio MVF.   +3 more
europepmc   +2 more sources

Pregnancy-related effect on elexacaftor, tezacaftor and ivacaftor pharmacokinetics in women with cystic fibrosis. [PDF]

Br J Clin Pharmacol
Aim The number of pregnancies among women with cystic fibrosis (wwCF) has steadily increased over the past decade. However, the pharmacokinetics (PK) of elexacaftor–tezacaftor–ivacaftor (ETI) during gestation remains uncharacterized, despite its widespread use in this population.
Magnas P, Bouazza N, Foissac F, Urien S, Froelicher-Bournaud L, Lui G, Guillemart V, Carlier N, Da Silva J, Fesenbeckh J, Kanaan R, Honoré I, Martin C, Treluyer JM, Tsatsaris V, Burgel PR, Benaboud S.   +16 more
europepmc   +2 more sources

Systematic Review of Nasal Endoscopy Scores in Cystic Fibrosis Patients Treated With Cystic Fibrosis Transmembrane Conductance Regulator Modulators. [PDF]

Pediatr Pulmonol
ABSTRACT Introduction Cystic fibrosis (CF) is a severe genetic disorder caused by pathogenic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, leading to multisystem complications including chronic rhinosinusitis and nasal polyposis. Recent advances in CFTR modulator therapies have revolutionized systemic disease control,
Gallardo R, Silva BS, Salgado LS, Ribeiro JD, Sakano E.   +4 more
europepmc   +2 more sources

Case Series of Sustained Fluid-Associated Weight Gain Following Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulator Therapy. [PDF]

Pediatr Pulmonol
Pediatric Pulmonology, Volume 61, Issue 9, September 2026.
Tillman EM, Lazutina A, Robinson RC, Colwell A, Brown CD.   +4 more
europepmc   +2 more sources

Mitogenome Characterization and Phylogenetic Insights Into Blind Mole Rats, <i>Nannospalax nehringi,</i> and <i>N. turcicus</i>, From Türkiye. [PDF]

Ecol Evol
This study presents the complete mitochondrial genomes of Nannospalax nehringi and N. turcicus from Türkiye and evaluates their phylogenetic relationships within Spalacidae. Both genomes exhibited conserved structure, and phylogenetic analyses using ML and BI approaches supported subfamily monophyly and a well‐supported clade for the two species ...
Yıldız B, Selçuk AY, Teber S, Baran M, Coşkun Y, Tez C, İbiş O.   +6 more
europepmc   +2 more sources

Ergenlerde, Akran İlişkileri ve Bağlanma Sitilleri ile Alkol Sigara Kullanımı Arasındaki İlişkinin İncelenmesi (Mağusa Örneği) [PDF]

, 2023
Rehberlik ve Psikolojik Danışmanlık - Yüksek Lisans Tezi. Lisansüstü Eğitim, Öğretim ve Araştırma Enstitüsü. Tez (Yüksek Lisans) - Doğu Akdeniz Üniversitesi, Eğitim Fakültesi, Eğitim Bilimleri Bölümü, 2023. Eş-Tez Danışmanı: Dr.
Dolu, Elife Kılbaş
core  

Tooth Decay Promotes Senescence in Dental Pulp Stem Cells, Modifying Their Biological and Proteomic Profiles. [PDF]

J Cell Physiol
ABSTRACT Dental caries is a prevalent oral health problem that significantly reduces an individual's quality of life; although, it can be effectively managed through restorative treatments. Even in cases where the caries does not reach the pulp, released microbial products from the lesion can still penetrate the pulp chamber, potentially inducing ...
Durukan SM, Acar MB, Tez BÇ, Şimşek A, Al-Sammarrie SHA, Günaydın Z, Güzel M, Süer BB, Güner ŞA, Güner H, Alessio N, Başaran KE, Gönen ZB, Özcan S.   +13 more
europepmc   +2 more sources

KKTC’de Gastronomi ve Mutfak Sanatları Bölümünde Okuyan Öğrencilerin Staj Deneyimleri ve Sektörde Kalma Eğilimleri [PDF]

, 2023
Gastronomi - Yüksek Lisans Tezi. Lisansüstü Eğitim, Öğretim ve Araştırma Enstitüsü. Tez (Yüksek Lisans) - Doğu Akdeniz Üniversitesi, Turizm Fakültesi, 2023. Eş-Tez Danışmanı: Dr. Mehmet Bahri Saydam ve Tez Danışmanı: Yrd. Doç. Dr. Özlem Altun.Bu çalışma,
Turan, Aliye Ela
core  

Türkiye’de Hadis İlminde Kadın Konulu Çalışmaların Meta-Sentez Analizi

Hadith, 2020
Hadis ilminde kadını konu edinerek hazırlanan tezlerin meta-sentez yöntemiyle incelenmesinin amaçlandığı bu çalışmada, “Türkiye’de, hadis ilminde hanımlara dair hazırlanan tezlerde kadına karşı nasıl bir algı ve yönelim vardır?” şeklindeki temel soruya ...
Emine Erdoğan Marsak
doaj   +1 more source