Results 81 to 90 of about 2,342 (200)
TecnoLógicas, 2011 En el presente trabajo se propone una metodología para la reducción de dimensión en representaciones tiempo frecuencia (TFRs) enfocada a la clasificación de bioseñales no estacionarias, que trata directamente su cantidad de datos irrelevantes y ...
Juan D. Martínez-Vargas +2 more
doaj
Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Advanced NanoBiomed Research, Volume 6, Issue 9, September 2026.Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
HemaSphere, Volume 10, Issue 9, September 2026.Abstract Relapsed/refractory (R/R) B‐cell lymphomas (B‐NHL) remain incurable, with limited predictive biomarkers to guide immunotherapy. Preclinical platforms that faithfully preserve the immune context and the viability of patient samples are critically needed for relevant high‐throughput drug testing.
Fabien Gava +20 more
wiley +1 more source
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen +3 more
wiley +1 more source
Ferroptosis: Newly Emerged Regulator for Human Disease
MedComm, Volume 7, Issue 9, September 2026.Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao +4 more
wiley +1 more source
Nanoparticle‐Mediated Therapy for Glioma: Advances and Prospects
MedComm – Oncology, Volume 5, Issue 3, September 2026.Various nanocarriers, including liposomes, dendrimers, exosomes and gold nanoparticles, are designed to penetrate the blood‐brain barrier and deliver chemotherapy, radiotherapy, immunotherapy, gene therapy, phototherapy, magnetic hyperthermia and sonodynamic therapy for glioma.
Wenqian Jiang +5 more
wiley +1 more source
The Fertility Effects of Reducing Implicit Childcare Subsidies: The Case of School Schedules
Journal of Policy Analysis and Management, Volume 45, Issue 4, Fall 2026.ABSTRACT Despite governments’ efforts to raise fertility through family‐support policies, birth rates continue to decline in high‐ and middle‐income countries. Some policies designed for other purposes, however, may function as implicit childcare subsidies.
Álvaro Muñiz‐Fernández
wiley +1 more source
Journal of Food Science, Volume 91, Issue 9, September 2026.ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by frequent activating mutations in the Kirsten rat sarcoma viral oncogene homologue (KRAS) and limited therapeutic options. Corchorus olitorius L., a traditional edible plant widely consumed in Asia, possesses documented anti‐inflammatory properties ...
Chiao‐Yun Tseng +6 more
wiley +1 more source
Chemistry – A European Journal, Volume 32, Issue 30, 13 August 2026.ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias +9 more
wiley +1 more source