Comparing Therapeutic Focused Ultrasound (tfUS) in Conjunction with Bosutinib versus Independent tfUS Administration Among Alzheimer’s Patients [PDF]
Brain Stimulation, 2021 AbstractBackgroundTo date, there are limited therapeutic options for the treatment or symptomatic relief of degenerative dementia [1]. There has been growing interest in the class of medications known as tyrosine kinase inhibitors, such as bosutinib, as a therapeutic intervention for dementia [2].
Norman Spivak
exaly +8 more sources
Brain StimulationIntroduction: Transcranial focused ultrasound (tFUS) can noninvasively modulate sensory pathways, but the cell-type-specific mechanisms underlying excitatory or inhibitory effects remain unclear. Here, we investigate how tFUS applied to the somatosensory
Huan Gao +5 more
exaly +6 more sources
Frontiers in Human NeuroscienceBackgroundThe nucleus accumbens (NAc) is a key node of the brain reward circuit driving reward-related behavior. Dysregulation of NAc has been demonstrated to contribute to pathological markers of addiction in substance use disorder (SUD) making it a ...
Bashar Badran, Xiaolong Peng
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Real-Time Acoustic Simulation Framework for tFUS: A Feasibility Study Using Navigation System
NeuroImage, 2023 Transcranial focused ultrasound (tFUS), in which acoustic energy is focused on a small region in the brain through the skull, is a non-invasive therapeutic method with high spatial resolution and depth penetration. Image-guided navigation has been widely utilized to visualize the location of acoustic focus in the cranial cavity. However, this system is
Hyungmin Kim, Wonhye Lee, So Hee Park
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Brain Stimulation, 2020 Background: Transcranial focused ultrasound (tFUS) is a noninvasive brain stimulation method that may modulate deep brain structures. This study investigates whether sonication of the right anterior thalamus would modulate thermal pain thresholds in ...
Jeffrey Borckardt +2 more
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Transcranial focused ultrasound induces source localizable cortical activation in resting state humans when applied concurrently with transcranial electric stimulation [PDF]
Nature CommunicationsThe effects of transcranial focused ultrasound (tFUS) on the human brain are poorly understood. Currently, the field is at odds with whether tFUS is subthreshold modulating the brain’s excitability towards other stimuli, producing suprathreshold neural ...
Joshua Kosnoff +6 more
doaj +3 more sources
Transcranial Focused Ultrasound (tFUS) and Transcranial Unfocused Ultrasound (tUS) Neuromodulation: From Theoretical Principles to Stimulation Practices [PDF]
Frontiers in Neurology, 2019 Transcranial focused ultrasound is an emerging technique for non-invasive neurostimulation. Compared to magnetic or electric non-invasive brain stimulation, this technique has a higher spatial resolution and can reach deep structures. In addition, both animal and human studies suggest that, potentially, different sites of the central and peripheral ...
Emma Falato +2 more
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Neuromodulation effects of low-intensity transcranial focused ultrasound in human, a systematic review focusing on motor and sensory functions [PDF]
Journal of NeuroEngineering and RehabilitationBackground Low-intensity transcranial focused ultrasound (tFUS) has emerged as a novel non-invasive brain stimulation technique with therapeutic potential for various neurological conditions.
Heng-Chen Ho +2 more
doaj +3 more sources
A thermal mechanism underlies tFUS neuromodulation [PDF]
Brain Stimulation, 2020 David Darrow +2 more
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Is transcranial focused ultrasound stimulation (tFUS) the next holy grail for treating depression? [PDF]
Brain Stimulation, 2021 Kevin Caulfield +2 more
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