Results 11 to 20 of about 36,083 (147)

MIGHTEE-H i: Possible interactions with the galaxy NGC 895 [PDF]

Monthly notices of the Royal Astronomical Society, 2023
The transformation and evolution of a galaxy is strongly influenced by interactions with its environment. Neutral hydrogen (H i) is an excellent way to trace these interactions.
B. Namumba, Javier Rom'an, J. Barroso, J. Knapen, Ianjamasimanana Roger, Elizabeth Naluminsa, G. Józsa, M. Korsaga, N. Maddox, B. Frank, S. Sikhosana, S. Legodi, C. Carignan, A. Ponomareva, T. Jarrett, D. Lucero, O. Smirnov, T. Hulst, D.J.Pisano, K. Małek, L. Marchetti, Mattia Vaccari, M. Jarvis, M. Baes, M. Meyer, E. Adams, J. Delhaize, Hao Chen, S. Rajohnson, S. Kurapati, I. Heywood, L. Verdes-Montenegro   +31 more
semanticscholar   +6 more sources

Modulation of RNA splicing associated with Wnt signaling pathway using FD-895 and pladienolide B [PDF]

Aging, 2022
Alterations in RNA splicing are associated with different malignancies, including leukemia, lymphoma, and solid tumors. The RNA splicing modulators such as FD-895 and pladienolide B have been investigated in different malignancies to target/modulate ...
Deepak Kumar, M. Kashyap, Zhe Yu, Ide T. Spaanderman, Reymundo Villa, T. Kipps, J. L. La Clair, M. Burkart, J. Castro   +8 more
semanticscholar   +2 more sources

Preclinical evidence for the effective use of TL-895, a highly selective and potent second-generation BTK inhibitor, for the treatment of B-cell malignancies

Scientific Reports, 2023
TL-895 (formerly known as M7583) is a potent, highly selective, adenosine triphosphate (ATP)-competitive, second-generation, irreversible inhibitor of Bruton’s tyrosine kinase (BTK).
S. Goodstal, Jing Lin, T. Crandall, Lindsey Crowley, Andrew T Bender, A. Pereira, Maria Soloviev, J. Wesolowski, Riham Iadevaia, Sven-Eric Schelhorn, Edith Ross, F. Morandi, Jianguo Ma, A. Clark   +13 more
semanticscholar   +2 more sources

Tumor-Induced Osteomalacia: A Systematic Clinical Review of 895 Cases

Calcified Tissue International, 2022
Tumor-induced osteomalacia (TIO) is a rare and largely underdiagnosed paraneoplastic condition. Previous reviews often reported incomplete data on clinical aspects, diagnosis or prognosis. The aim of this study was to present a systematic clinical review
A. Bosman, A. Palermo, J. Vanderhulst, S. J. D. de Beur, S. Fukumoto, S. Minisola, Weibo Xia, J. Body, M. Zillikens   +8 more
semanticscholar   +1 more source

Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 individuals across 989 unique drugs and 286 conditions in England.

The Lancet Healthy Longevity, 2022
BACKGROUND Randomised controlled trials (RCTs) inform prescription guidelines, but stringent eligibility criteria exclude individuals with vulnerable characteristics, which we define as comorbidities, concomitant medication use, and vulnerabilities due ...
Yen Yi Tan, Václav Papez, Wai Hoong Chang, Stefanie H Mueller, S. Denaxas, A. Lai   +5 more
semanticscholar   +1 more source

Stereochemical Control of Splice Modulation in FD-895 Analogues [PDF]

, 2023
Highly functionalized skeletons of macrolide natural products gain access to rare spatial arrangements of atoms, where changes in stereochemistry can have a profound impact on the structure and function.
Trieger, Kelsey A, Chan, Warren C, Jamieson, Catriona HM, La Clair, James J, Burkart, Michael D   +4 more
core   +3 more sources

A Phase (Ph) 2 Study of TL-895, a Highly Selective, Novel Covalent BTK Inhibitor (BTKi), in Patients (pts) with Treatment-Naïve (TN) and Relapsed/Refractory (R/R) BTKi-Naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

Blood, 2023
Background: Covalent BTKi have become the backbone of CLL/SLL therapy. Through improved target kinase selectivity, second generation BTKi offer improved safety with potentially better efficacy, yet compartmental clearance leading to complete remission
John C. Byrd, D. Woszczyk, Á. Illés, Wojciech Jurczak, Dominik Chraniuk, Krzysztof Giannopoulos, Nataliia Mikhailova, Peter Illconzai, S. Bhat, Nataliya Romanyuk, G. Usenko, O. Kuchkova, J. Chandler, Elizabeth Bilotti, Annalise Shen, Jean P. Cheung, S. Verstovsek, J. Mcgreivy, Wayne Rothbaum, Maciej Kaźmierczak   +19 more
semanticscholar   +1 more source

High‐resolution morphology and surface photometry of KIG 685 and KIG 895 with ARGOS+LUCI using the Large Binocular Telescope [PDF]

Astronomical Notes - Astronomische Nachrichten, 2019
We aim to refine the sample of isolated early-type galaxies in the AMIGA catalogue via high resolution imaging. Here we report the result from a pilot study investigating two candidates, KIG 685 and KIG 895, in K-band with the laser guide star and ...
R. Rampazzo, M. Uslenghi, I. Georgiev, A. Cattapan, L. Verdes-Montenegro, M. Bonaglia, J. Borelli, L. Busoni, Wolfgang Gäessler, D. Magrin, Antonina Marino, Paola Mazzei, T. Mazzoni, D. Peter, S. Rabien, R. Ragazzoni, Mathias Rosensteiner   +16 more
semanticscholar   +1 more source

Scalable Synthesis of 17S-FD-895 Expands the Structural Understanding of Splice Modulatory Activity

, 2020
Summary While splice modulators have entered clinical trials, limited clinical efficacy in splicing factor mutation-driven malignancies, such as acute myeloid leukemia, has remained a challenge.
W. Chan, J. L. La Clair, B. León, Kelsey A. Trieger, M. Slagt, M. Verhaar, D. Bachera, M. T. Rispens, R. Hofman, Vincent de Boer, R. van der Hulst, R. Bus, P. Hiemstra, Michael Neville, Kyle A. Mandla, Joshua S. Figueroa, C. Jamieson, M. Burkart   +17 more
semanticscholar   +1 more source

Anatomy of density: measurable factors that constitute urban density

Buildings & Cities, 2021
Serious concerns about global warming have been translated into urgent calls for increasing urban densities, as higher densities are associated with lower carbon emissions from both vehicles and buildings.
Shlomo Angel, Patrick Lamson-Hall, Zeltia Gonzalez Blanco   +2 more
doaj   +1 more source