Results 61 to 70 of about 18,397 (205)

Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis

Neurobiology of Disease, 2007
Infantile neuronal ceroid lipofuscinosis (INCL) is caused by deficiency of the lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1). We have investigated the onset and progression of pathological changes in Ppt1 deficient mice (Ppt1−/−) and the ...
Catherine Kielar, Lucy Maddox, Ellen Bible, Charlie C. Pontikis, Shannon L. Macauley, Megan A. Griffey, Michael Wong, Mark S. Sands, Jonathan D. Cooper   +8 more
doaj   +1 more source

The Foxb1‐expressing neurons of the ventrolateral hypothalamic parvafox nucleus project to defensive circuits [PDF]

, 2016
The parvafox nucleus is an elongated structure that is lodged within the ventrolateral hypothalamus and lies along the optic tract. It comprises axially located parvalbumin (Parv)-positive neurons and a peripheral cuff of Foxb1-expressing ones. In the
Alvarez-Bolado, Gonzalo, Bilella, Alessandro, Celio, Marco R.   +2 more
core   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Thalamic reticular nucleus induces fast and local modulation of arousal state

eLife, 2015
During low arousal states such as drowsiness and sleep, cortical neurons exhibit rhythmic slow wave activity associated with periods of neuronal silence.
Laura D Lewis, Jakob Voigts, Francisco J Flores, L Ian Schmitt, Matthew A Wilson, Michael M Halassa, Emery N Brown   +6 more
doaj   +1 more source

Thalamic reticular nucleus in the pathophysiology of schizophrenia

Neural Regeneration Research
Abstract Mechanistic analyses on schizophrenia have traditionally focused on corticolimbic structures such as the prefrontal cortex, hippocampus, and amygdala, given their established roles in cognition. However, the thalamus, a critical hub that interconnects these regions, has garnered comparatively less attention.
Gonzalo Flores, David J. Apam-Castillejos, Hannaford Edwards, Victor M. Magdaleno-Madrigal, Juan Nacher, Hiram Tendilla-Beltrán, Lalit K. Srivastava   +6 more
openaire   +2 more sources

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

A thalamic reticular networking model of consciousness [PDF]

, 2010
[Background]: It is reasonable to consider the thalamus a primary candidate for the location of consciousness, given that the thalamus has been referred to as the gateway of nearly all sensory inputs to the corresponding cortical areas. Interestingly, in
Byoung-Kyong Min, VA Lamme, S Dehaene, S Zeki, EG Jones, JD Schmahmann, JD Schmahmann, EG Jones, CJ Shatz, H Kennedy, DN Pandya, TA Hackett, MM Mesulam, EG Jones, EG Jones, IA Ilinsky, M Steriade, UB Schambra, S Wang, Y Shu, M Steriade, GB Lundkvist, XJ Wang, EG Jones, JM Fuster, DA McCormick, G van Luijtelaar, RK Berdiev, CT Yen, CR Houser, D Pinault, D Pinault, L Domich, DA McCormick, M Steriade, G Avanzini, MA Long, M Xu, C Mulle, M Steriade, J Szabadics, CS Herrmann, CS Herrmann, AK Engel, P Fries, M Steriade, JR Huguenard, DA McCormick, JA Hartings, SM Sherman, G Marini, T Bal, M Steriade, M Steriade, D Contreras, RB Mistry, SM Sherman, M Deschenes, FS Lo, M Steriade, SM Sherman, EJ Ramcharan, TG Weyand, DL Schacter, M Conley, JW Crabtree, DA Lozsadi, SM Sherman, YT So, JB Mattingley, ZI Nanobashvili, DJ Uhlrich, V Henkel, K Imai, G Winterer, YA Bayazit, P Nencini, R Bachner-Melman, JR Park, R Desimone, J Stehberg, F Crick, SL Bressler, JM Fuster, DE Rumelhart, CM Gray, JM Fuster, W James, S Fecteau, DJ Barraclough, F Manes, S van Gaal, JA Johnson, MA Vanderhasselt, TJ Buschman, S Grimault, P Malhotra, S Yantis, S Itami, AC Nobre, P Andrade, P Bartolomeo, MI Posner, EA Maylor, S Yantis, XJ Yu, DO Hebb, J Duncan, RA Weddell, VC Raos, SM Lee, C Bucherelli, PA McCormick, D Pinault, C Koch, B Libet, S Bodovitz, HL Roediger, RT Watson, VA Lamme, S Zeki, HC Lau, L Weiskrantz, NR McFarland, C Asanuma, M Sidibe, JM Fuster, PD Cheney   +127 more
core   +3 more sources

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, EarlyView.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

The what, which, when, why and who of Off responses in the auditory system

The Journal of Physiology, EarlyView.
Abstract figure legend In this article, we will first review ‘What’ different mechanisms are involved in the generation of Off responses at the sub‐cortical and cortical level of the auditory system. Then, we evaluate ‘Which’ stimulus properties elicit Off responses at the different levels of the auditory system.
Jean‐Marc Edeline, Robert C. Liu
wiley   +1 more source

Dynamics of action potential initiation in the GABAergic thalamic reticular nucleus in vivo. [PDF]

PLoS ONE, 2012
Understanding the neural mechanisms of action potential generation is critical to establish the way neural circuits generate and coordinate activity.
Fabián Muñoz, Pablo Fuentealba
doaj   +1 more source