Twisting the End Game: How Telomere Chromatin Modifications Shape Telomere Maintenance
Aging Cell, Volume 25, Issue 9, September 2026.Chromatin modifications on telomeres are linked to the mode of telomere DNA replication. A coupled feedforward loop model is proposed based on these to lock the ALT cancer cells in this alternative mode of telomere replication. ABSTRACT Cell division inevitably shortens telomeric DNA owing to the end‐replication problem.
Jie Wang +8 more
wiley +1 more source
Efficacy of Reticulocyte Haemoglobin Equivalent-Guided Versus Transferrin Saturation-Guided Iron Supplement Protocol in Haemodialysis Patients: A Multicenter Cluster Randomized Controlled Trial. [PDF]
Nephrology (Carlton)Suttaluang C +10 more
europepmc +1 more source
Case Report: life-threatening haemothorax due to extramedullary haematopoiesis in a patient with Beta-thalassaemia major. [PDF]
Front Med (Lausanne)Wéry L +3 more
europepmc +1 more source
Clinical and Translational Science, Volume 19, Issue 9, September 2026.ABSTRACT Posaconazole is a triazole antifungal agent used for prophylaxis and treatment of invasive fungal diseases. Posaconazole has high inter‐individual variability in dose‐exposure relationship and benefits from therapeutic drug monitoring (TDM). Adult studies report particularly high rates of subtherapeutic exposure among intensive care unit (ICU)
Kathryn Pavia +2 more
wiley +1 more source
The β-goblin gene architecture in individuals with and without sickle cell disease in Nigeria: Implications for β-thalassaemia trait diagnosis. [PDF]
Afr J Lab MedBabalola OA +7 more
europepmc +1 more source
Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
Filippo Russo +6 more
wiley +1 more source
Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders
The FEBS Journal, Volume 293, Issue 17, Page 5149-5169, September 2026.Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo +6 more
wiley +1 more source
International Wound Journal, Volume 23, Issue 9, September 2026.ABSTRACT To compare clinical and laboratory characteristics of transfusion‐dependent and non‐transfusion‐dependent beta thalassaemia patients with leg ulcers, and to identify contributing and protective factors We retrospectively reviewed 12 patients with beta thalassaemia and leg ulcers (seven transfusion‐dependent and five non‐transfusion‐dependent ...
Sacha El Khoury +7 more
wiley +1 more source
Evaluation of Liver Iron Accumulation With Liver Elastography and Apparent Diffusion Coefficient in Children With Thalassaemia Major. [PDF]
J Med Imaging Radiat OncolKaya M, Konukoğlu O, Güngör C.
europepmc +1 more source
Journal of the American Geriatrics Society, Volume 74, Issue 9, Page 2564-2572, September 2026.ABSTRACT Background Restrictive transfusion (Hb < 7 g/dL) is recommended for most perioperative patients, but the optimal threshold for those with cardiovascular disease or Hb 7–10 g/dL remains uncertain. The Perioperative Transfusion Trigger Score (POTTS), which integrates adrenaline requirement, FiO2, temperature, and angina history, may standardize ...
Shucong Liang +9 more
wiley +1 more source