Results 61 to 70 of about 22,512 (233)

Heterozygous Beta‐Thalassaemia in Pregnancy: Two Rare Causes of Severe Fetal Anemia Requiring Intrauterine Blood Transfusions

Prenatal Diagnosis, EarlyView.
ABSTRACT Aim In this article, we present two cases of severe fetal hemolytic anemia based on a beta‐thalassaemia trait inherited from a single parent. Results These cases, presented at 20 and 28 weeks' gestation, necessitated intra‐uterine blood transfusions.
Eva van der Meij, Frans J. W. Smiers, Tamara T. Koopmann, Ingrid Krapels, Kaatje LePoole, Enrico Lopriore, Johanna M. Middeldorp, Claudia S. Ootjers, Volkher Scharnhorst, Hubertina C. J. Scheepers, Cornelis L. Harteveld, E. J. T. (Joanne) Verweij   +11 more
wiley   +1 more source

An investigation of the protective effect of alpha+-thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana

, 2014
Introduction: Several factors influence the severity of Plasmodium falciparum; here, we investigate the impact of alpha+-thalassaemia genotype on P. falciparum parasitemia and prevalence of severe anaemia amongst microcytic children from Kumasi, Ghana.
Smith, C.L., C. Opoku‐Okrah, M. Parry, Gordge, M.P., E. Kweku Nakua, C. L. Smith, T. Abgenyega, Robertson, C.E., C. Robertson, Opoku-Okrah, C., Kweku Nakua, E., M. Gordge, Parry, M., Abgenyega, T.   +13 more
core   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia

eLife, 2019
Severe forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart’s hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity and health burden of α-thalassaemia in the region
Carinna Hockham, Supachai Ekwattanakit, Samir Bhatt, Bridget S Penman, Sunetra Gupta, Vip Viprakasit, Frédéric B Piel   +6 more
doaj   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Screening of concurrent alpha-Thalassaemia 1 in beta-Thalassaemia carriers [PDF]

, 2006
Thalassaemia is an inherited blood disorder and is a significant public health problem in Malaysia, with many not knowing they carry gene for thalassaemia. The two major forms are alpha and beta thalassaemia.
George, E., Kuldip, K., Zubaidah, Z., Chong, Y.M., Tan, J., Rahimah, A.   +5 more
core   +1 more source

Thalassaemia in Pakistan

Journal of Islamic International Medical College, 2018
Thalassaemia is the commonest single gene disorder of globin chain synthesis all over the world . It is found as thalassaemia minor when the defect is inherited from one of the parents and as thalassaemia major when the defect is inherited from both of ...
Suhaib Ahmed
doaj  

Addressing adherence to treatment: a longstanding concern. The patients’ perspective

Thalassemia Reports, 2014
Adherence to treatment is a great concern for patients who need long-life treatment. Thalassaemia is an inherited disease for whose treatment team-working is of a considerable importance.
Mahmoud Hadipour Dehshal
doaj   +1 more source

Psychological morbidity among children with transfusion dependent β-thalassaemia and their parents in Sri Lanka.

PLoS ONE, 2020
BACKGROUND:Thalassaemia is a chronic disease which requires lifelong treatment in a majority. Despite recent advances in the medical care, minimal attempts are made to improve psychological health in these patients.
Sachith Mettananda, Ravindu Peiris, Hashan Pathiraja, Miyuru Chandradasa, Dayananda Bandara, Udaya de Silva, Chamila Mettananda, Anuja Premawardhena   +7 more
doaj   +1 more source

A systematic review on thalassaemia screening and birth reduction initiatives cost to success [PDF]

Introduction: Thalassaemia has been prevalent with high morbidity and mortality rates since 1925. Although there is a lack of systematic review on the costs of prevention that has yielded reductions in thalassaemia prevalence, this review will show a ...
Abd Rahim, Azrin Syahida, Abd. Rahim, Nour El Huda, Jaafar, Safurah   +2 more
core