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Genetics in Medicine, 2010 Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated at 1 in 100,000 throughout the world and 1 in 10 ...
Galanello R, ORIGA, RAFFAELLA
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Hematology, 2004
Abstract New developments in the epidemiology, treatment and prognosis of thalassemia have dramatically altered the approach to the care of affected patients, and these developments are likely to have an even greater impact in the next few years.
Alan R, Cohen +4 more
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Abstract New developments in the epidemiology, treatment and prognosis of thalassemia have dramatically altered the approach to the care of affected patients, and these developments are likely to have an even greater impact in the next few years.
Alan R, Cohen +4 more
openaire +2 more sources
Pediatric Clinics of North America, 2013
The thalassemia syndromes are hemoglobin disorders that result from significantly reduced or absent synthesis of either the α- or β-globin chains. The result is a chronic hemolytic anemia with ineffective erythropoiesis and bone marrow overstimulation.
Alissa, Martin, Alexis A, Thompson
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The thalassemia syndromes are hemoglobin disorders that result from significantly reduced or absent synthesis of either the α- or β-globin chains. The result is a chronic hemolytic anemia with ineffective erythropoiesis and bone marrow overstimulation.
Alissa, Martin, Alexis A, Thompson
openaire +2 more sources
American Journal of Hematology, 1977
AbstractThe current concepts of α‐thalassemia including incidence, genetics, clinical spectrum and diagnosis are reviewed. Speculation concerning clinical application of the molecular biology of α‐thalassemia is also presented.
J G, Adams, M H, Steinberg
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AbstractThe current concepts of α‐thalassemia including incidence, genetics, clinical spectrum and diagnosis are reviewed. Speculation concerning clinical application of the molecular biology of α‐thalassemia is also presented.
J G, Adams, M H, Steinberg
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Hematology/Oncology Clinics of North America, 2023
Edward J, Benz, Vijay G, Sankaran
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Edward J, Benz, Vijay G, Sankaran
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CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia
New England Journal of Medicine, 2021David M Altshuler +2 more
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