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PATHOPHYSIOLOGY OF THALASSEMIA
Annals of the New York Academy of Sciences, 1980The clinical manifestations in homozygous thalassemia may be attributed to the defect in hemoglobin synthesis (Figure 16). It is best typified by beta thalassemia, where excess alpha chains accumulate to form intracytoplasmic erythrocytic inclusions. This leads to anemia, bone marrow hyperplasia, osteoporosis, hemosiderosis, and organ failure.
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Clinical Classification, Screening and Diagnosis for Thalassemia
Hematology/Oncology Clinics of North America, 2018Chayamon Takpradit +1 more
exaly
Thalassemia trait or thalassemia intermedia
American Journal of Hematology, 2001openaire +2 more sources

