Results 171 to 180 of about 32,643 (191)

Neutropenia in Patients with Thalassemia Major.

Blood, 2004
Abstract Monitoring of the neutrophil count has become an important issue in the management of thalassemia patients after the introduction of the new oral chelator deferiprone, as this chelator has been associated with agranulocytosis and milder neutropenias.
GALANELLO, RENZO, ORIGA, RAFFAELLA
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Hepcidin and β-thalassemia major

Blood, 2013
In this issue of Blood, Pasricha et al evaluated serum hepcidin and its putative pathological suppressor growth differentiation factor-15 (GDF-15) in patients with β-thalassemia major before and after transfusion, in the context of erythropoietic activity and iron loading.
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Update on Survival in Thalassemia Major

Hemoglobin, 2009
Long-term follow-up of cohorts of patients treated in high-income countries has shown a progressive improvement in life expectancy. Myocardial toxicity from iron overload has been the major cause of mortality; however, there has been a substantial decline in cardiac deaths in recent years, related to switching high-risk patients from subcutaneous ...
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Renal Enlargement in Thalassemia Major

Radiology, 1971
Twenty-four patients with thalassemia major and no urinary tract complaints underwent excretory urography. The kidneys were large bilaterally in 17 patients; 2 other patients had enlargement of the left kidney. The autopsies of 13 patients were reviewed; the kidneys were large in all 13.
Dische Mr, Grossman H, Winchester Ph, Canale   +3 more
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Auditory Involvement in Thalassemia Major

Acta Haematologica, 1979
The auditory function of 75 children affected by homozygous beta0-thalassemia, managed with a low transfusion scheme and treated irregularly with low doses of desferrioxamine, and of 75 controls were examined. In 12 patients a mild bilateral conductive hearing impairment due to bony hypertrophy and/or adenoid hypertrophy was found.
Mallardi, G. Cornacchia, Argiolu F, Antonio Cao, P. Cossu, De Virgiliis S, G. Sanna, Puxeddu P   +7 more
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Survival and Disease Complications in Thalassemia Major

Annals of the New York Academy of Sciences, 1998
Abstract: We studied survival and disease complications in 1,146 patients with thalassemia major, born from January 1, 1960 to December 31, 1987. At last follow‐up, in March 1997, probability of survival to age 20 years was 89% and to age 25 years was 82% for patients born in the years 1970‐1974.
BORGNA PIGNATTI C, RUGOLOTTO S, DE STEFANO P, PIGA, Antonio Giulio, DI GREGORIO F, GAMBERINI MR, SABATO V, MELEVENDI C, CAPPELLINI MD, VERLATO G.   +9 more
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Hepatitis in children with thalassemia major

1992
Since thalassemia major patients are transfusion dependent, they are at a particularly high risk of contracting post-transfusion hepatitis. In this study, 36 transfusion-dependent children were followed up for evidence of viral hepatitis. Of 23 with increased ALT levels, 17 were anti-CMV and 12 were anti-HCV positive, 9 were positive for both CMV and ...
Giovanni Nigro, S. Mattia, A. Petruccelli, Mario Midulla, Gloria Taliani, U. Bartmann, T. Perrone, Pasquale Pisano, R. Vitolo, S. Maiozzi   +9 more
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Hepatocellular carcinoma in thalassemia major

Medical and Pediatric Oncology, 1986
AbstractThe occurrence of hepatocellular carcinoma in a 22‐year‐old man with thalassemia major is reported. As a result of transfusional hemochromatosis, this patient had already developed diabetes, hypogonadism, heart failure, and the sicca syndrome; he was serum and tissue HBsAg negative.
BORGNA, Caterina, P. De Stefano, F. Sessa, AVATO, Francesco Maria   +3 more
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Transplantation for thalassemia major: alternative donors

Current Opinion in Hematology, 2016
Purpose of review Lack of a human leukocyte antigen (HLA)-matched family donor is a major obstacle limiting the use of allogeneic hematopoietic stem cell transplantation (HSCT) to cure thalassemia major. Use of alternative donors, if found well tolerated enough, may be a viable option for transplantation in this setting ...
Locatelli F., Merli P., Strocchio L.
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Fertility and Pregnancy in Thalassemia Major

Annals of the New York Academy of Sciences, 2005
Abstract: Over the last 15 years, 22 women with thalassemia major have completed 29 pregnancies at the Royal Hospital in London. The major pre‐pregnancy issues, medications, and pregnancy care are reviewed. Experience suggests that, with proper care and guidance, pregnancies among women with thalassemia major are practical and can have successful ...
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