Results 101 to 110 of about 764,332 (226)

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

Prospective assessment of regional myocardial perfusion before and after coronary revascularization surgery by Quantitative Thallium-201 scintigraphy

, 1983
Because thallium-201 uptake relates directly to the amount of viable myocardium and nutrient blood flow, the potential for exercise scintigraphy to predict response to coronary revascularization surgery was investigated in 47 consecutive patients.
Holt, Nina D., Beller, George A., Watson, Denny D., Harry L. Wellons, Nina D. Holt, George A. Beller, Denny D. Watson, George J. Taylor, Gibson, Robert S., Crosby, Ivan K., Wellons, Harry L., Robert S. Gibson, Taylor, George J., Ivan K. Crosby   +13 more
core   +1 more source

Mapping Immunity With Cutting‐Edge Spatial Biology and Tissue Cytometry Innovations

MedComm, Volume 7, Issue 6, June 2026.
This review explores how spatial biology integrates multiplexed imaging and tissue cytometry to reveal immune organization within native tissue contexts. ABSTRACT The immune system operates within organized tissue landscapes, where spatial relationships between cells shape the nature and outcome of immune responses.
Lilibeth Cárdenas‐Piedra, Selwin G. Samuel, Felicitas Mungenast, Dinesh Yasothkumar, Rupert C. Ecker, Jyotsna Batra   +5 more
wiley   +1 more source

Split dose thallium-201 dipyridamole imaging: A new technique for obtaining thallium images before and immediately after an intervention

, 1983
A technique for performing thallium-201 imaging after two separate injections of the tracer, closely spaced temporally, was developed (split dose thallium technique). Thirty patients were studied; 23 had significant coronary artery disease and 7 did not.
Lim, Yean L., Okada, Robert D., Block, Peter C., Boucher, Charles A., Pohost, Gerald M., Rothendler, James   +5 more
core   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

An Evaluation of Thallium-201 as a Tumour Imaging Agent [PDF]

, 1988
I evaluated thalllum-201 chloride as a tumour imaging agent. I studied the time course of Tl--201 uptake in various tumours in order to establish the best time for imaging tumours following injection of the tracer.
Sehweil, Ali Mahmoud
core  

Effects of farming practices on the performance of fish pond polyculture assessed by trophic modeling

Journal of the World Aquaculture Society, Volume 57, Issue 3, June 2026.
Abstract This study aimed to identify species compositions that use resources more efficiently and recommend management practices for extensive and semi‐intensive pond polyculture by modeling food webs and calculating performance indicators. We monitored 8 polyculture fish ponds managed by fish farmers that had contrasting fish species compositions in ...
Purco Ralaiarison Ralien, Angela Larivain, Marc Roucaute, Michael S. Corson, Alexandrine Pannard, Joël Robin, Léo Girard, Mathieu Guérin, Marielle Thomas, Thomas Lecocq, Julie Coudreuse, Sarah Nahon, Kazi Ahmed Kabir, Joël Aubin   +13 more
wiley   +1 more source

Selective loss of Cx40 and conduction abnormalities underlie enhanced atrial fibrillation susceptibility in a HFpEF model in male mice

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Heart failure with preserved ejection fraction (HFpEF) is frequently complicated by atrial fibrillation (AF), yet the mechanisms underlying AF vulnerability prior to or independent of extensive structural remodeling remain incompletely understood.
Kohei Kawajiri, Satoshi Iwamiya, Leo Yaga, Masahiro Yamazoe, Kensuke Ihara, Yurie Soejima, Tetsuo Sasano   +6 more
wiley   +1 more source

Thallium 201 Myocardial Imaging

, 1979
In recent years technological advancements in nuclear medicine have resulted in increasing interest in the use of radioisotope techniques in the evaluation of cardiac disease, and cardiovascular nuclear medicine has developed into a useful noninvasive ...
Cowley, Michael J.
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