Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer +14 more
wiley +1 more source
Transboundary pipelines and the Arctic: legal issues
, 2016 Alexander N. Vylegzhanin, Urzula Moskwa
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Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source
Post-2000 faster ENSO phase transitions amplify autumn sea ice loss in the Laptev-East Siberian Sea. [PDF]
Sci AdvWang C +6 more
europepmc +1 more source
The Case of a 28‐Year‐Old Man With Gradually Progressive Proximal Leg Weakness
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This is a case of a 28‐year‐old man who presented with a 6‐month history of gradually progressive proximal leg weakness and pain that worsened on exercise and was relieved by rest. He had no symptoms in his upper limbs. Apart from intermittent mild ptosis and diplopia, he had no other cranial nerve symptoms.
Melody T. Asukile +3 more
wiley +1 more source
The Arctic Ocean is a net sink for anthropogenic lead deposited into the Atlantic Ocean. [PDF]
Nat CommunKrisch S +5 more
europepmc +1 more source
Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa +10 more
wiley +1 more source
Contrasting Life History Characteristics Between Riverine and Lacustrine Anadromous Arctic Char (<i>Salvelinus alpinus</i>) in the Western Canadian Arctic. [PDF]
Ecol EvolGallagher CP, Zhu X, Lea EV, Howland KL.
europepmc +1 more source
Chemical Ozone Loss in the Arctic Polar Stratosphere : an analysis of twelve years of satellite observations [PDF]
, 2004 Simone Tilmes
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