Results 111 to 120 of about 147,399 (308)
Advanced Healthcare Materials, EarlyView.A droplet microfluidic platform is employed to enable high‐throughput, uniform tumor spheroid generation for evaluating siRNA‐loaded nanomedicines at the protein level. As a proof of concept, breast (MCF‐7) and brain (U87 MG) cancer cell lines are investigated using this platform, revealing penetration profiles and therapeutic responses between the two
Ling Liu +4 more
wiley +1 more source
Widespread decline in hydrological monitoring threatens Pan‐Arctic Research [PDF]
, 2002 Operational river discharge monitoring is declining in both North America and Eurasia. This problem is especially severe in the Far East of Siberia and the province of Ontario, where 73% and 67% of river gauges were closed between 1986 and 1999 ...
Lammers, Richard B. +2 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He +10 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum +5 more
wiley +1 more source
Next Steps to Reform the Regulations Governing Offshore Oil and Gas Planning and Leasing [PDF]
, 2015 The Department of the Interior manages offshore oil and gas activities in federal waters. While the agency has proposed and/or enacted important improvements to the rules that govern some of those activities, it has not modernized the regulations that ...
Hartsig, Andrew +3 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij +8 more
wiley +1 more source
Optimal control of the heave motion of marine cable subsea-unit systems [PDF]
, 1995 One of the key problems associated with subsea operations involving tethered subsea units is the motions of support vessels on the ocean surface which can be transmitted to the subsea unit through the cable and increase the tension.
Huang, S., Vassalos, D.
core
Advanced Healthcare Materials, EarlyView.The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li +9 more
wiley +1 more source
Canada’s Arctic Policy: Prospects For Cooperation In A Warming World [PDF]
Central European Journal of International & Security Studies, 2011 This assessment of the Arctic is divided in to four sections. First, the true value of the region is defined in terms of its environmental, geostrategic, economic and socio-cultural importance.
Brian Karmazin
doaj