Results 51 to 60 of about 147,399 (308)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Disagreements over animal rights issues have prevented the EU from gaining full observer status at the Arctic Council [PDF]
, 2014 Although analyses of the EU’s external relations have typically focused on regions to the east or south of the continent, the EU has also developed a growing interest in the Arctic. Clive Archer provides an overview of the EU’s involvement in the Arctic,
Archer, Clive
core
On motion analysis and elastic response of floating offshore wind turbines [PDF]
, 2020 Wind energy industry is expanded to offshore and deep water sites, primarily due to the stronger and more consistent wind fields. Floating offshore wind turbine (FOWT) concepts involve new engineering and scientific challenges.
Hayatdavoodi, Masoud, Lamei, Azin
core +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The need to know: governing a region and its economy [PDF]
, 2015 This paper investigates the ways in which the economy has been incorporated into the political reasoning and practice of region-building in the Barents Region among experts.
Tennberg, Monica
core +3 more sources
Det arktiske samarbeidet sett fra Sápmi: Samerådets perspektiv på Arktisk råd – og veien fremover
Internasjonal PolitikkArktisk råd er et unikt mellomstatlig samarbeid der seks urfolksorganisasjoner har plass ved bordet som permanente deltagere. Urfolk i Arktis etablerte et samarbeid tidlig på 1970-tallet og var klare for å kreve en plass ved bordet da statene i Arktis ...
Per Olof Nutti
doaj +1 more source
Sustainable Development, Natural Resource Extraction, and the Arctic: The Road Ahead [PDF]
, 2016 Sustainable development has emerged as an integral nexus, linking together critically important global issues including environmental stewardship and economic growth. Understanding sustainable development demands a close analysis of evolving definitions,
Canuel, Edward
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The Arctic council as an international organization of a new type
Международная аналитика, 2017 The article emphasizes that the Arctic Council (AC) is a high level forum of cooperation, based on taking decisions by consensus that are carried out by member states on a voluntary basis and in accordance with their national interests.
L. S. Voronkov, A. A. Smirnova
doaj +1 more source