Results 91 to 100 of about 3,769,047 (404)

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian   +26 more
wiley   +1 more source

Timber selection for sustainable construction in Bali: integrating Multi-Criteria Life Cycle Assessment (MC-LCA) with vernacular agrospatial wisdom from Balinese architectural manuscripts

open access: yesJournal of Asian Architecture and Building Engineering
Timber selection in traditional Balinese architecture is governed not only by environmental and structural factors but also by cultural logics that connect architecture, kinship, and agroecological cycles.
I Made Agus Mahendra   +5 more
doaj   +1 more source

Stitching together research and data to create evidence for innovation

open access: yesJournal of Learning Development in Higher Education
In this paper, colleagues from the University of the Arts London shared insights regarding how they were, first, using data to adapt their offers to enhance students’ learning experiences and outcomes and, second, developing a data approach to examine ...
Emma Shackleton   +3 more
doaj   +1 more source

Arts, Culture and Californians Charting Arts Participation and Organizations in a Vast, Diverse State [PDF]

open access: yes, 2011
Arts and culture play a significant role in the daily lives of Californians. The state is noteworthy for the avid participation of its people, the diversity and abundance of its arts organizations and the varied regional characteristics of its arts ...
Ann Markusen   +3 more
core  

Nanoscale Mapping of the Subcellular Glycosylation Landscape

open access: yesAdvanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter   +4 more
wiley   +1 more source

Twelve potluck principles for social design

open access: yesDiscern, 2022
The term ‘social design’ is used in a variety of contexts, but—or maybe because of this—it is far from clear what it means. The starting point for this paper is that there is a need for stronger and more critical community discourse to understand and ...
Christian Nold   +3 more
doaj  

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

open access: yesAdvanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang   +11 more
wiley   +1 more source

California's Arts and Cultural Ecology [PDF]

open access: yes, 2011
Californians create, organize, and nurture one of the world's richest arts and cultural ecologies. Across diverse landscapes, they preserve traditions and unveil cutting-edge new artwork. As artists, cultural leaders, community-builders, and arts lovers,
Ann Markusen   +3 more
core   +1 more source

Comment on “De Novo Reconstruction of 3D Human Facial Images from DNA Sequence”

open access: yesAdvanced Science, EarlyView.
This comment examines AI‐driven DNA‐based facial reconstruction, focusing on the Difface model. While such technologies promise biomedical and forensic applications, they pose significant ethical, legal, and methodological challenges. We emphasize transparency, benchmarking, and rigorous validation to avoid misinterpretation and misuse.
Jennifer K. Wagner   +3 more
wiley   +1 more source

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