Results 41 to 50 of about 305,279 (357)

Association between C-reactive protein with all-cause mortality in ELSA-Brasil cohort [PDF]

, 2020
Background: High-sensitive C-reactive protein (hsCRP) has been proposed as a marker of incident cardiovascular disease and vascular mortality, and it may also be a marker of non-vascular mortality.
Alvim Matos, Sheila M., Azevedo, Douglas R. M., Barreto, Sandhi M., Cappuccio, Francesco P., Giatti Gonçalves, Luana, Griep, Rosane H., Ji, Chen, Maluf, Chams B., Miller, Michelle A., Ribeiro, Luiz P., Vidigal, Pedro G.   +10 more
core   +3 more sources

Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1

Scientific Reports, 2018
Nitro-substituted 1,3-benzothiazinones (nitro-BTZs) are mechanism-based covalent inhibitors of Mycobacterium tuberculosis decaprenylphosphoryl-β-D-ribose-2′-oxidase (DprE1) with strong antimycobacterial properties.
Adrian Richter, Ines Rudolph, Ute Möllmann, Kerstin Voigt, Chun-wa Chung, Onkar M. P. Singh, Michael Rees, Alfonso Mendoza-Losana, Robert Bates, Lluís Ballell, Sarah Batt, Natacha Veerapen, Klaus Fütterer, Gurdyal Besra, Peter Imming, Argyrides Argyrou   +15 more
doaj   +1 more source

Poems

Revista Alicantina de Estudios Ingleses, 1994
Introduction (from Songs of Innocence) ; The Garden of Love (from Songs of Experience) = Introducción (de Cantos de inocencia) ; El jardín del amor (de Cantos de experiencia) / translated by Natividad Fernández de Bobadilla Lara.
Blake, William, Fernández de Bobadilla Lara, Natividad   +1 more
doaj   +1 more source

Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline

FASEB BioAdvances, 2020
Background Whole‐cell phenotypic screening is the driving force behind modern anti‐tubercular drug discovery efforts. Focus has shifted from screening for bactericidal scaffolds to screens incorporating target deconvolution.
Christopher Burke, Monika Jankute, Patrick Moynihan, Ruben Gonzalez del Rio, Xiaojun Li, Jorge Esquivias, Joël Lelièvre, Jonathan A. G. Cox, James Sacchettini, Gurdyal S. Besra   +9 more
doaj   +1 more source

Samuel Daniel's The Complaint of Rosamond and the arrival of Tasso's Armida in England [PDF]

, 2010
This essay argues that the earliest English work to offer a sustained poetic engagement with the figure of Armida, the celebrated pagan enchantress from Tasso’s Gerusalemme liberata (1581), is Daniel’s The Complaint of Rosamond (1592).
Lawrence, Jason
core   +2 more sources

Plasmodium RNA triphosphatase validation as antimalarial target

International Journal for Parasitology: Drugs and Drug Resistance
Target-based approaches have traditionally been used in the search for new anti-infective molecules. Target selection process, a critical step in Drug Discovery, identifies targets that are essential to establish or maintain the infection, tractable to ...
Sonia Moliner-Cubel, Noemi Bahamontes-Rosa, Ane Rodriguez-Alejandre, Pamela M. Nassau, Argyrides Argyrou, Anshu Bhardwaja, Rachel C. Buxton, David Calvo-Vicente, Bernadette Mouzon, William McDowell, Alfonso Mendoza-Losana, Maria G. Gomez-Lorenzo   +11 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

Nature Communications, 2017
Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in ...
David A. Baker, Lindsay B. Stewart, Jonathan M. Large, Paul W. Bowyer, Keith H. Ansell, María B. Jiménez-Díaz, Majida El Bakkouri, Kristian Birchall, Koen J. Dechering, Nathalie S. Bouloc, Peter J. Coombs, David Whalley, Denise J. Harding, Ela Smiljanic-Hurley, Mary C. Wheldon, Eloise M. Walker, Johannes T. Dessens, María José Lafuente, Laura M. Sanz, Francisco-Javier Gamo, Santiago B. Ferrer, Raymond Hui, Teun Bousema, Iñigo Angulo-Barturén, Andy T. Merritt, Simon L. Croft, Winston E. Gutteridge, Catherine A. Kettleborough, Simon A. Osborne   +28 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Ezra Pound’s Representations of Sexual Intercourse and the Female Genitalia in The Cantos

Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2020
This paper focuses on the ways in which Ezra Pound chose to represent the female genitalia in his Cantos. The discussion of these representations is based on the work of Poundian scholars such as Peter Makin, Robert Casillo, and Jean-Michel Rabaté who ...
Emilie Georges
doaj   +1 more source