Results 161 to 170 of about 1,585,834 (305)

Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort

open access: yesAnnals of Neurology, EarlyView.
Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov   +42 more
wiley   +1 more source

Redox‐Activated Probes Enable High‐Contrast Live Imaging of Native Postsynaptic Scaffolds

open access: yesAngewandte Chemie International Edition, EarlyView.
Sylives are modified fluorescent peptides for high‐contrast live imaging of inhibitory (gephyrin) and excitatory (PSD‐95) postsynaptic scaffolds in native neurons. Clean labeling requires low nanomolar probe levels, whereas uptake needs micromolar cell‐penetrating peptide (CPP).
Christiane Huhn   +10 more
wiley   +1 more source

Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases

open access: yesAngewandte Chemie International Edition, EarlyView.
Charged aryl‐ethynyl phosphonamidic and phosphonic acids are introduced as low‐reactivity electrophiles for peptide‐based activity probes that enable selective, target‐specific profiling of protein tyrosine phosphatases. The probes show no off‐target cysteine reactivity and engage only the interacting phosphatase in global proteomic analysis.
Eleftheria Poulou   +4 more
wiley   +1 more source

Correction: Adetunji et al. DNA Methylation: A Key Regulator in Male and Female Reproductive Outcomes. <i>Life</i> 2025, <i>15</i>, 1109. [PDF]

open access: yesLife (Basel)
Adetunji AO   +8 more
europepmc   +1 more source

Impact of Seasonal Composition on the Long‐Term Performance of Post‐Consumer Recycled Polypropylene

open access: yesJournal of Applied Polymer Science, EarlyView.
Ten batches of post‐consumer polypropylene recyclate were examined over a period of 15 months. Despite identical MFR and density specifications, there were significant differences in their composition, affecting mechanical performance. Elongation at break and crack resistance varied particularly strongly.
Jessica Hinczica   +7 more
wiley   +1 more source

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