Results 211 to 220 of about 126,328,189 (308)

TRAFFICGEN: a multi-agent LLM orchestration for smart mobility and emergency corridor pre-emption. [PDF]

Front Artif Intell
Soni G, Khekare G, Kumar Y, Rupaak S.
europepmc   +1 more source

Advancing Understanding of Subjective Liveability for People With Disability

Australian Journal of Social Issues, EarlyView.
ABSTRACT Modern liveability frameworks aim to enhance health and well‐being through equity‐based measures across built, natural, social, and economic environments, yet they often overlook the perspectives of people with disability. This study explored expectations of liveable neighbourhoods among adults with diverse disability experiences in urban and ...
Maria Hobbs, Kim Jose, Ceridwen Owen, Verity Cleland   +3 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Surface dynamics of glassy polymers with different molecular weight distributions. [PDF]

Nat Commun
Wang S, Zhu Y, Fu Y, Zhang X, Zuo B, Dai L, Chai Y.   +6 more
europepmc   +1 more source

Strengthening Responses to Older Adult Abuse: A Review of Contextual Prevention Strategies in Australian Policy

Australian Journal of Social Issues, EarlyView.
ABSTRACT Older adult abuse is a significant social issue that has attracted necessary attention in Australian policy. Yet, the scope of abuse prevention strategies proposed within these policies has not been systematically reviewed, nor has their alignment with evidence‐informed frameworks been assessed.
Madeline Lee, Emily Moir, Nadine McKillop   +2 more
wiley   +1 more source

Characterization of a Fungal Modular Polyketide Synthase System Reveals an Unusual Strategy for Polyketide Chain Initiation

Angewandte Chemie, EarlyView.
Fungal modular polyketide synthases (PKSs) remain largely unexplored. Functional characterization of the LasC/LasD assembly line established its role in strasseriolide C biosynthesis and suggested an unexpected strategy for chain initiation, in which a malonyl unit is transferred from the module 2 acyl carrier protein (ACP) domains to the loading ACP ...
Qiaolin Ji, Chao Peng, Shuhan He, Bin‐Tao Peng, Wei‐Guang Wang, Yudai Matsuda   +5 more
wiley   +2 more sources

Understanding the implementation, impact and sustainability of Bristol's unhealthy commodity advertising restrictions policy: a qualitative systems-based study of stakeholder perspectives. [PDF]

BMJ Public Health
Harding SK, Nobles J, Horwood J, Brockman R, Buckland G, Toumpakari Z, Nairn A, Blake S, Cummins S, Jago R, Sillero Rejon C, de Vocht F.   +11 more
europepmc   +1 more source

Accessibility and Alignment of Trans‐Cleavage Substrates Modulate the Kinetics of Cas12a Ribonucleoprotein

Angewandte Chemie, EarlyView.
Two key binding events that collectively determine the catalytic efficiency of trans‐cleavage: (1) the substrate passing through the gap between the REC and NUC domains, determined by Kpass, and (2) the alignment of the substrate with the catalytic triad of the ribonucleoprotein, determined by Kalign.
Jianyu Hu, Wei Feng, Hongquan Zhang, X. Chris Le   +3 more
wiley   +2 more sources

Enhanced power and transferability for genetics-driven metabolomic biomarker discovery in admixed American cohorts

Orešković T, Jin D, Trichia E, Aguilar-Ramirez D, Xu Y, Foguet C, Hubbard T, Turner M, Vergara-Lope A, Fernández-Chirino L, Gil L, Hill MR, Alegre-Díaz J, Berumen J, Lewington S, Emberson JR, Kuri-Morales P, Tapia-Conyer R, Torres JM, Inouye M.   +19 more
europepmc   +1 more source