Results 31 to 40 of about 326,229 (306)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Przegląd KonstytucyjnyThe author has analysed and translated the judgment of the European Court of Human Rights of 11 July 2022 in the case of Kavala v. Turkey, application no.
Mikołaj Wolanin
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Central European Public Administration Review, 2017 This contextual paper tackles a rather under-researched topic of Council of Europe’s possible impact on national administrative law. It seeks to examine how one of its instruments – Recommendations of the Committee of Ministers of the Council of Europe –
Agnė Andrijauskaitė
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Constant government reshuffles are bad for policy, government, and accountability [PDF]
, 2013 Ministerial reshuffles are part and parcel of British government. While prime ministers often find them attractive, David Cameron has resisted the temptation to chop and change too much, making a virtue out of stability but occasionally being criticised ...
Kippin, Sean
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2014 Conflicts connected with territorial and national contradictions took place in the neighbouring states of Russia, and on Russian territories, that led the Russian government to the need of associating with these states.
Gontar Sergey Mikhaylovich
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Sweets, Henry Hayes, 1872-1952 (SC 3055) [PDF]
, 2016 Finding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 3055. Mimeographed letter, 20 March 1906, of Henry H. Sweets, Louisville, Kentucky, Secretary, Executive Committee, Ministerial Education and Relief, of the ...
Folklife Archives, Manuscripts &
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source