Results 91 to 100 of about 409,591 (393)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

From International Mandate to National Legislation: Pakistan’s Response to Erga Omnes Obligations on Child Sexual Abuse

Journal of Legal Studies
This article critically assesses Pakistan’s compliance with erga omnes obligations under the Convention on the Rights of the Child (CRC) concerning sexual abuse of children.
Ali Muhammad Imran
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Child labour in affluent societies: law's influence on attitudes and practices [PDF]

The thesis traces the influence of law on the institutional practices and attitudes concerned with child labour, using a comparative approach. It has been suggested, that the adoption of International Instruments relating to children and young people, in
Heesterman, Wiebina
core  

An Introduction To The Developing Jurisprudence Of The Rights Of The Child [PDF]

, 1997
The Convention on the Rights of the Child was adopted by the United Nations General Assembly on November 20, 1989.\u27 At the time of the International Law Association\u27s 1996 International Law Weekend, 187 countries had ratified the ...
Cohen, Cynthia Price
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Healthcare professionals’ understanding of children’s rights: a systematic review of the empirical evidence-base

Systematic Reviews
Background The concept of children’s rights emerged during the 1980s and emphasised the role of children as active participants in matters which concern them.
Sahar Mazied Alshammari, Mark A. Linden, Helen Kerr, Helen Noble   +3 more
doaj   +1 more source

The United Nations Convention of the Rights of the Child: A Feminist Landmark

, 1997
The United Nations Convention on the Rights of the Child,1 adopted by the General Assembly on November 20, 1989, is a ground-breaking human rights treaty for many reasons.
Cohen, Cynthia Price
core  

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Children’s rights and needs during war: the case of adolescents in Israel

Frontiers in Psychology
IntroductionThis study aims to examine the attainment of rights and needs of adolescents during the war following the October 7th 2023 terror attack on Israel.
Yonat Rum, Erez Milsthen, Heba F. Zedan, Tali Gal   +3 more
doaj   +1 more source