Results 91 to 100 of about 409,263 (344)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Journal of Legal StudiesThis article critically assesses Pakistan’s compliance with erga omnes obligations under the Convention on the Rights of the Child (CRC) concerning sexual abuse of children.
Ali Muhammad Imran
doaj +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
The Voice Of The Child in International Child Abduction Proceedings Under the 1980 Hague Convention [PDF]
, 2019 With the thirtieth anniversary of the United Nations Convention on the Rights of the Child (hereafter the UNCRC) being celebrated in 2019, this timely project was undertaken to consider the practical application of the right of the child to participate ...
Freeman, M., Taylor, N., and Schuz, R. +1 more
core
POST-ADOPTION CONTACT REFORM: COMPOUNDING THE STATE-ORDERED TERMINATION OF PARENTHOOD? [PDF]
, 2014 The Children and Families Act 2014 pursues the twin policies of increasing the number of children adopted out of compulsory state care and reducing the scope for court-ordered contact between such children and their birth families. Building upon previous
Sloan, Brian
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Systematic ReviewsBackground The concept of children’s rights emerged during the 1980s and emphasised the role of children as active participants in matters which concern them.
Sahar Mazied Alshammari +3 more
doaj +1 more source
Child labour in affluent societies: law's influence on attitudes and practices [PDF]
The thesis traces the influence of law on the institutional practices and attitudes concerned with child labour, using a comparative approach. It has been suggested, that the adoption of International Instruments relating to children and young people, in
Heesterman, Wiebina
core
Developing the Substantive Best Interests of Child Migrants: A Call for Action [PDF]
, 2012 This Article attempts to accomplish two goals. First, it provides an overview of what is known and unknown about international child migrants. While this Conference will focus to some degree on child migrants in the United States, this Article shows how ...
Schoenholtz, Andrew I.
core +3 more sources
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source