Results 81 to 90 of about 1,950,048 (268)

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Development of an evidence-based evaluation framework for digital health software products

Scientific Reports
Current frameworks and standards for evaluation of digital health software products (DHSPs) are fragmented and may not cover the spectrum of what stakeholders consider most important.
Jennifer C. Goldsack, Colby Holliday, Yashoda Sharma, Doug Mirsky, Cole Zanetti, Benjamin Vandendriessche   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Digital health equity for older populations

The Lancet: Digital Health, 2023
The Lancet Digital Health
doaj   +1 more source

Multi-Scale Geometric Feature Extraction and Global Transformer for Real-World Indoor Point Cloud Analysis

Mathematics
Indoor point clouds often present significant challenges due to the complexity and variety of structures and high object similarity. The local geometric structure helps the model learn the shape features of objects at the detail level, while the global ...
Yisheng Chen, Yu Xiao, Hui Wu, Chongcheng Chen, Ding Lin   +4 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Pregnancy in a pandemic: inequalities in maternal health

The Lancet: Digital Health, 2022
The Lancet Digital Health
doaj   +1 more source

The Digital Archive and the Politics of Digitization

, 2022
In this paper I will discuss key parameters of the politics of digitisation within a broader historical and global context with the aim to encourage further debate on its implications for historical research. In the first part, I will outline the global dimensions of the politics of digital cultural heritage with a particular focus on developments ...
openaire   +2 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Empowering women in health technology

The Lancet: Digital Health, 2022
The Lancet Digital Health
doaj   +1 more source