Results 81 to 90 of about 1,776,394 (268)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Every breath you take, every move you make

The Lancet: Digital Health, 2020
The Lancet Digital Health
doaj   +1 more source

Digital therapy for depression in multiple sclerosis

The Lancet: Digital Health, 2023
The Lancet Digital Health
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Decolonising health data

The Lancet: Digital Health, 2023
The Lancet Digital Health
doaj   +1 more source

Reclaiming Human Agency in the Age of Artificial Intelligence

Journal of Moral Theology
The text, in continuity with the group’s previous publication and following _Antiqua et Nova_, highlights the difference between the prevailing AI definition of intelligence as rational action and problem-solving (often influenced by behaviorism and ...
AI Research Group of the Centre for Digital Culture, Paul Scherz, Brian Patrick Green   +2 more
doaj   +1 more source

Inequalities in internet use among older people between 2004 and 2021

Journal of Digital Social Research
Although research already examined sociodemographic profiles of older internet (non-)users, it is unknown how combinations of sociodemographic factors relate to internet (non-)use.
Jorrit Campens, Anina Vercruyssen, Werner Schirmer, Nico De Witte, on behalf of the Digital Ageing Consortium   +4 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Leaving cancer diagnosis to the computers

The Lancet: Digital Health, 2020
The Lancet Digital Health
doaj   +1 more source

Metaphorically Speaking: Possibilities of Theatre Performance in the Digital Age

Caracteres: Estudios Culturales y Críticos de la Esfera Digital, 2012
This essay reflects on the quality of the theatre performance as medium in the digital age through a discussion of the theatre of Peter Handke. The aim is to make manifest and engage with habits of thought and perception shaped by the digital, as well as
Ioana Juncan
doaj