Results 51 to 60 of about 146,811,730 (309)

Digital humanities and digital social reading [PDF]

Digital Scholarship in the Humanities, 2019
Abstract Prominent among the social developments that the web 2.0 has facilitated is digital social reading (DSR): on many platforms there are functionalities for creating book reviews, ‘inline’ commenting on book texts, online story writing (often in the form of fanfiction), informal book discussions, book vlogs, and more.
Simone Rebora, Peter Boot, Federico Pianzola, Brigitte Gasser, J. Berenike Herrmann, Maria Kraxenberger, Moniek M. Kuijpers, Gerhard Lauer, Piroska Lendvai, Thomas C. Messerli, Pasqualina Sorrentino   +10 more
openaire   +5 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Digital Collections and Digital Collecting Practices [PDF]

Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems, 2015
Reference is increasingly made to ‘digital collections’, yet this term encompasses accumulated digital objects of varying form, purpose and value. We review social science literature on mate-rial collections and draw from in-depth interviews with 20 peo-ple in the UK in order to offer a clearer understanding of what constitutes a digital collection and
Rebecca D. Watkins, Abigail Sellen, Siân E. Lindley   +2 more
openaire   +2 more sources

Errata to Sound Hashing Modes of Arbitrary Functions, Permutations, and Block Ciphers

IACR Transactions on Symmetric Cryptology, 2020
In ToSC 2018(4), Daemen et al. performed an in-depth investigation of sound hashing modes based on arbitrary functions, permutations, or block ciphers. However, for the case of invertible primitives, there is a glitch.
Aldo Gunsing, Joan Daemen, Bart Mennink
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

From the Digitized to the Digital Library

D-Lib Magazine, 2001
Historical Social Research.
openaire   +3 more sources

Digital (In)Equality, Digital Inclusion, Digital Humanism

12th ACM Conference on Web Science Companion, 2020
From its inception, the World Wide Web has been intended to be a force for social good. But there are many barriers and obstacles, a situation commonly characterized as the Digital Divide. Several billion people especially in the Global South do not have access to Internet/Web for reasons of lacking (affordable) infrastructure, poverty, low literacy ...
Anna Bon, Hans Akkermans
openaire   +3 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Digital Transformation and Digital Leadership [PDF]

Healthcare Informatics Research, 2019
Healthcare does not transform itself; it is transformed by us. The people coming to the Biomedical Informatics society are those who wish to make changes. In my opinion, this is what digital leadership is. Through this article, I will share what is happening in the world around us in terms of Biomedical Informatics.
openaire   +3 more sources