Results 71 to 80 of about 18,256,021 (363)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

La governamentalità algoritmica: radicalizzazione e strategia immunitaria del capitalismo e del neoliberalismo? [PDF]

open access: yesLa Deleuziana, 2016
This article is a set of reflections on the question: ‘what is completely new in algorithmic governmentality compared to capitalism and neoliberalism?’ The following text is thus some preliminary, temporary and definitively uncertain intuitions in ...
Antoinette Rouvroy
doaj  

Digital (In)Equality, Digital Inclusion, Digital Humanism

open access: yes12th ACM Conference on Web Science Companion, 2020
From its inception, the World Wide Web has been intended to be a force for social good. But there are many barriers and obstacles, a situation commonly characterized as the Digital Divide. Several billion people especially in the Global South do not have access to Internet/Web for reasons of lacking (affordable) infrastructure, poverty, low literacy ...
Anna Bon, Hans Akkermans
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

The Montreal Statement on Sustainability in the Digital Age

open access: yes, 2020
the Montreal Statement on Sustainability in the Digital Age is a collective statement from an international group of business, government, and science leaders highlights that we cannot achieve a climate-safe, sustainable, and equitable future without ...
Sustainability in the Digital Age
core   +1 more source

Errata to Sound Hashing Modes of Arbitrary Functions, Permutations, and Block Ciphers

open access: yesIACR Transactions on Symmetric Cryptology, 2020
In ToSC 2018(4), Daemen et al. performed an in-depth investigation of sound hashing modes based on arbitrary functions, permutations, or block ciphers. However, for the case of invertible primitives, there is a glitch.
Aldo Gunsing, Joan Daemen, Bart Mennink
doaj   +1 more source

Computing Logarithms Digit-by-Digit

open access: yesBRICS Report Series, 2004
In this work, we present an algorithm for computing logarithms of positive real numbers, that bares structural resemblance to the elementary school algorithm of long division. Using this algorithm, we can compute successive digits of a logarithm using a 4-operation pocket calculator.
openaire   +2 more sources

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Learning from the early adopters: developing the digital practitioner

open access: yes, 2014
This paper explores how Sharpe and Beetham’s Digital Literacies Framework which was derived to model students’ digital literacies, can be applied to lecturers’ digital literacy practices. Data from a small-scale phenomenological study of higher education
Liz Bennett   +2 more
core   +2 more sources

Machine learning clinical prediction models for acute kidney injury: the impact of baseline creatinine on prediction efficacy

open access: yesBMC Medical Informatics and Decision Making, 2023
Background There are many Machine Learning (ML) models which predict acute kidney injury (AKI) for hospitalised patients. While a primary goal of these models is to support clinical decision-making, the adoption of inconsistent methods of estimating ...
Amir Kamel Rahimi   +6 more
doaj   +1 more source

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