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: Within the framework of the Algerian vision that emphasizes the importance of digital transformation in all sectors, including the health sector, the Algerian Ministry of Health intends to develop an integrated digital health system, through the ...
Analytical Sight on the Algerian Digital Health Strategy 2023-2027
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The potential of digital molecular diagnostics for infectious diseases in sub-Saharan Africa [PDF]
There is a large gap between diagnostic needs and diagnostic access across much of sub-Saharan Africa, particularly for infectious diseases which inflict a substantial burden of morbidity and mortality.
Cunnington, Aubrey J +1 more
core +1 more source
Digital Collections and Digital Collecting Practices [PDF]
Reference is increasingly made to ‘digital collections’, yet this term encompasses accumulated digital objects of varying form, purpose and value. We review social science literature on mate-rial collections and draw from in-depth interviews with 20 peo-ple in the UK in order to offer a clearer understanding of what constitutes a digital collection and
Rebecca D. Watkins +2 more
openaire +1 more source
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Digital humanities and digital social reading [PDF]
Abstract Prominent among the social developments that the web 2.0 has facilitated is digital social reading (DSR): on many platforms there are functionalities for creating book reviews, ‘inline’ commenting on book texts, online story writing (often in the form of fanfiction), informal book discussions, book vlogs, and more.
Simone Rebora +10 more
openaire +5 more sources
Massively parallel digital transcriptional profiling of single cells
Characterizing the transcriptome of individual cells is fundamental to understanding complex biological systems. We describe a droplet-based system that enables 3′ mRNA counting of tens of thousands of single cells per sample.
Grace X. Y. Zheng +34 more
semanticscholar +1 more source
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Advancing Australia as a digital economy: an update to the national digital economy strategy [PDF]
The Government’s 2011 National Digital Economy Strategy (the 2011 NDES) set the goal of Australia becoming a leading digital economy by 2020. In doing so, it nominated eight goals to position Australia as a world leader in broadband connectivity and the ...
core
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
Summary: It is expected that emerging digital gene expression (DGE) technologies will overtake microarray technologies in the near future for many functional genomics applications.
M. Robinson, Davis J. McCarthy, G. Smyth
semanticscholar +1 more source

