Results 71 to 80 of about 653,631 (317)

Investigation into the clandestin use of corticosteroids among the Algerian population. [PDF]

open access: yesBatna Journal of Medical Sciences
Introduction. Self-medication practices are gaining popularity now more than ever. It is the use of one or more drugs for treatment without the advice of a doctor. It can involve any type of drug, including corticosteroids.
Aouatef BEYAZ   +3 more
doaj   +1 more source

A qualitative study of professionals’ perspectives on the ethics of medically-delivered safer injection education for people who inject drugs

open access: yesBMC Medical Ethics, 2023
Background In this qualitative analysis we aimed to explore addiction physicians’ perspectives on safer injection education for people who inject drugs, especially: (1) on possible means of introducing safer injection education in the medical environment,
Anastasia Demina   +2 more
doaj   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

open access: yesAdvanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi   +10 more
wiley   +1 more source

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

open access: yesAdvanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma   +10 more
wiley   +1 more source

Fitness to Drive Policy in Inpatient Setting: Findings of QI Project

open access: yesBJPsych Open
Aims Background: Nature and degree of mental illness can impair abilities of patients to drive safely which puts their own safety and safety of others at risk.
Sajid Mahmood   +4 more
doaj   +1 more source

Ethical implications of digital communication for the patient-clinician relationship: analysis of interviews with clinicians and young adults with long term conditions (the LYNC study)

open access: yesBMC Medical Ethics, 2018
Background Digital communication between a patient and their clinician offers the potential for improved patient care, particularly for young people with long term conditions who are at risk of service disengagement.
Agnieszka Ignatowicz   +8 more
doaj   +1 more source

Willful Infringement and the Evidentiary Value of Opinion Letters After Knorr–Bremse v. Dana [PDF]

open access: yes, 2005
Recently, the Federal Circuit in Knorr-Bremse v. Dana overruled almost twenty years of precedent by striking down the adverse inference doctrine, which had created a negative presumption against any alleged patent infringer for failing to obtain and ...
Stowell, Joshua
core   +1 more source

Fiduciary Issues in Federal Banking Regulation [PDF]

open access: yes, 1993
It is argued that the fiduciary duty being claimed by banking regulators against depository institutions arising out of the S&L scandal is actually a distinct statutory ...
Baxter, Lawrence G.
core   +2 more sources

Natural Variations of ZmRLR1 Mediate the Root Lodging Resistance of Maize by Regulating Root Ascorbate and Auxin Homeostasis

open access: yesAdvanced Science, EarlyView.
Root lodging severely limits crop yield and quality. We reveal that ZmRLR1, a plasma membrane b‐type cytochrome, regulates lodging resistance in maize through dual roles: modulating intracellular redox balance and functioning as a novel component of clathrin‐mediated endocytosis to influence auxin homeostasis. Moreover, natural variations in the ZmRLR1
Wenshuai Lv   +7 more
wiley   +1 more source

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

open access: yesAdvanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy