Results 211 to 220 of about 128,346,560 (329)

Factors Contributing to Improved Bone Mineral Density in Patients With Transfusion-Dependent Thalassemia. [PDF]

Kaohsiung J Med Sci
Hsu CY, Hsiao HP, Chiou SS, Lin PC, Liao YM, Hsu WY, Wang TH, Wang SY.   +7 more
europepmc   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Beyond the Eye of the Tiger: A Case Report of Adult-Onset Pantothenate Kinase-Associated Neurodegeneration Mimicking Progressive Supranuclear Palsy-Parkinsonism. [PDF]

Cureus
Moradian A, Memari K, Rodriguez SA, Manuel J, Williams S, Cohen P, Lazo LP.   +6 more
europepmc   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Postnatal Iron Supplementation Fails to Fully Rescue Brain Metal and Transcriptional Defects Caused by Nutrition-Based Gestational Iron Deficiency. [PDF]

J Nutr
Cubello J, Ambeskovic A, Salois G, Wang L, Peterson DR, Proschel C, Mayer-Proschel M.   +6 more
europepmc   +1 more source

Oropos in the Early Iron Age

, 1998
openaire   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Antenatal maternal anaemia and infant brain structure: high-field (3 T) and ultra-low-field (64 mT) MRI findings from South Africa. [PDF]

Brain Commun
Ringshaw JE, Zieff MR, Bourke NJ, Casella C, Bradford LE, Williams SR, Herr D, Miles M, Bennallick C, Khula South Africa Data Collection Team, Deoni S, O'Muircheartaigh J, Stein DJ, Alexander DC, Jones DK, Williams SCR, Donald KA, Khula South Africa Data Collection Team .   +17 more
europepmc   +1 more source

Anode‐Free Sodium Metal Batteries: From Materials Design to System‐Level Integration

Advanced Science, EarlyView.
Anode‐free sodium metal batteries hold no sodium reserve, so every inefficiency becomes permanent loss. Resolving the inventory into reversible, dead, and chemically bound fractions exposes what Coulombic efficiency hides. Practical 500‐cycle operation requires above 99.95%, a threshold few systems meet under lean electrolyte and high areal capacity ...
Hamid Hussain, Shazaib Ali, Muhammad Ali, Samia Aman, Moazzam Ali, Ufra Naseer, Sajid Farooq, Asif Mahmood, Sailing He, Yinzhu Jiang, Muhammad Yousaf   +10 more
wiley   +1 more source

Population genomics, demography, and circum-Baltic connectivity of Early Medieval southwestern Finland. [PDF]

Genome Biol
O'Sullivan RJ, Nordfors U, Saari NJ, Majander K, Taavitsainen JP, Salo K, Rohrlach AB, Salmela E, Lamnidis TC, Traverso L, Krause J, Peltola S, Onkamo P.   +12 more
europepmc   +1 more source