Results 41 to 50 of about 112,683 (310)

11. A Genuine Intercultural Ethics Requires a Decolonized Pluriversal Dialogue Between the Colonizers and the Colonized

Journal of Moral Theology
To promote not simply an intercultural ethics, but rather a “genuine intercultural ethics” that is contemporarily under attack, the chapter suggests an appropriated “decolonial ethics.” I argue that such an ethics should embrace a “pluriversal dialogue”
Jude Thaddaeus Buyondo
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Thinkableness of All Thoughts and the Irreplaceability of Pictures: Cora Diamond on Religious Belief

Religions
Under the ideas of ‘hinges’ and ‘pictures’, as these relate to deep disagreement, Wittgenstein’s view of religious belief is a multifaceted challenge to conceptions of thought-world relations.
Sofia Miguens
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

(Batı Felsefesi Çerçevesinde) Epistemolojik ve Etik Açıdan İnanç

Dini Araştırmalar, 2015
Epistemology and ethics of belief is one of the most important and serious problems in philosophy and philosophy of religion. Is there, for belief, any standard or criteion to be rational and, if any, what are?
Abdullatif Tüzer
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Inhibitors and facilitators of compliance with professional ethics standards: nurses’ perspective

BMC Nursing
Introduction The clinical practices of nurses should be in accordance with the principles of professional ethics. Respecting professional ethics principles depends on several factors.
Shahram Sharifi, Hossein Ebrahimi, Shahla Elyaszadeh, Arman Latifi, Mohammad Taghi Khodayari, Maedeh Alizadeh   +5 more
doaj   +1 more source

Success Perception Embedded in the Experience of Adverse Social Selection of a Post-Communist Transition Society [PDF]

Belvedere Meridionale, 2014
Based on the four different types of success ethics described by De Vitis – Rich (1996), a questionnaire was created and used in a representative sample (N = 1007) of the contemporary Hungarian society to gain understanding of the dominant social ...
SZABÓ, Éva, KÉKESI, Márk
doaj   +1 more source