Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
In practical unlicensed communications in TV band, radio devices have to identify, at first, the transmission opportunities, that is, the portion of the spectrum licensed for broadcasting services unoccupied in a certain region at certain time, that is ...
M. Fadda +4 more
doaj +1 more source
From Brexit to European renewal: the fracture of the social contract underlies the current turmoil [PDF]
The European Commission’s 2017 White Paper on reform of the EU focussed on completion of the single market and firmer governance of the Euro. However, it wholly ignored inequality and social justice.
Room, Graham
core
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
Integration of public transport in polish and EU documents and examples of solutions for integration of public transport in Poland and in the world [PDF]
The article presents the problems and the importance of integration of public transport on the basis of Polish and EU documents relating to public transport, as well as gives examples of solutions that integrate urban public transport in Poland and ...
Katarzyna SOLECKA
doaj
Sustainable mobility at the EU level – in the new transport white paper
CORPUS – The SCP Knowledge Hub - First Policy Meets Research Workshop on Sustainable Mobility. Funded by the European Commission in FP7. Szentendre, Hungary, 5/6 May 2011 The main message of the contribution in four points: (1) The environmental targets for 2050 (sixty percent emission decrease, oil dependence decrease) are based on a very progressive ...
openaire +1 more source
Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz +11 more
wiley +1 more source
Eligible assets, investment strategies and investor protection in light of modern portfolio theory: Towards a risk-based approach for UCITS. ECMI Policy Briefs No. 2, 18 September 2006 [PDF]
As the European Commission is currently in the process of preparing its White Paper on the enhancement of the EU framework for investment funds (scheduled for November 2006), now is a good time to reflect on whether the UCITS framework needs a radical ...
Casey, Jean-Pierre.
core
Hierarchical word clustering - automatic thesaurus generation [PDF]
In this paper, we propose a hierarchical, lexical clustering neural network algorithm that automatically generates a thesaurus (synonym abstraction) using purely stochastic information derived from unstructured text corpora and requiring no prior word ...
Austin, J, Hodge, V J
core +1 more source
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu +14 more
wiley +1 more source

