Results 191 to 200 of about 2,244,036 (262)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Triple-Negative Breast Cancer: Molecular Subtypes; Immune Escape; Limitations of Current Immunotherapy; and the BTLA/HVEM/CD160 Axis as an Emerging Target. [PDF]

Curr Issues Mol Biol
Rapoport BL, Anderson R, van Tonder D, Smit T, Rossouw TM, Benn CA, Steel HC.   +6 more
europepmc   +1 more source

The dose makes the poison: Mechanisms of cytotoxicity of high-dose AAV vectors. [PDF]

Mol Ther Adv
Flotte TR.
europepmc   +1 more source

Hijacking the bone niche: mechanistic insights into bone metastasis in breast cancer. [PDF]

Bone Res
Wu J, Deng M, Ye F, Deng W, Wu Z, Zheng X, Song C, Zou Y, Tang H.   +8 more
europepmc   +1 more source

Lewis Y (Le^y) orchestrates leukocyte trafficking and inflammatory remodeling in leprosy patients from the Brazilian Amazon. [PDF]

Immunol Res
Almeida S, da Cruz EDRM, de Loiola RDSP, Corvelo TCO.   +3 more
europepmc   +1 more source

In Vitro hRPTEC TERT1 Model for Uranium-Induced Nephrotoxicity Pathway Study. [PDF]

J Toxicol
Frerejacques M, Powell V, Giraud S, Manoury A, Bouvier-Capely C, Hauet T, Steichen C, Guéguen Y.   +7 more
europepmc   +1 more source

Diverse assimilation pathways drive carbon fixation in the global ocean

Baltar F, González J.
europepmc   +1 more source