Navigating the Emotional Challenges of Grade School: The Influence of Early Family Strains and a Lack of Parental Responsiveness on Trajectories of Anxiety and Depressive Symptoms. [PDF]
Fam ProcessLopez M +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The Sense of Security and Associated Factors Among Older Home Care Clients: A Register Study. [PDF]
Scand J Caring SciMira P +4 more
europepmc +1 more source
A Winged-Helix Family Member Is Involved in a Steroid Hormone-Triggered Regulatory Circuit**This work was supported by NIH Grants RO1-DK-40082 (to M.M.S.) and T32-DK-0703 (to D.M.D.). [PDF]
, 1998 Diane M. Dean +2 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Reasoning of family forest owners – survey of forest management and biodiversity protection problems
, 2010 Teppo Hujala +5 more
openalex +1 more source
A family of Koszul self-injective algebras with finite Hochschild cohomology [PDF]
, 2011 Alison E. Parker, Nicole Snashall
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Family medicine at the heart of health systems: Reaching for evidence
Annals of Global Health, 2016 K.D. Rouleau +6 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source