Results 121 to 130 of about 73,656 (257)
Nature CommunicationsTropical cyclones (TCs) displace millions every year. While TCs pose hardships and threaten lives, their negative impacts can be reduced by anticipatory actions like evacuation and humanitarian aid coordination.
Pui Man Kam +5 more
doaj +1 more source
Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency
Advanced Materials, EarlyView.As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang +12 more
wiley +1 more source
Advanced Materials, EarlyView.Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol +16 more
wiley +1 more source
Advanced Materials Interfaces, EarlyView.Strongly adhered cells align with concentric circular ridges and exhibit predominantly tangential motion, whereas weakly adhered cells fail to follow topographical guidance and display enhanced radial inward motion. ABSTRACT Living cells establish long‐range orientational order through collective alignment, giving rise to topological defects whose ...
Prasoon Awasthi +4 more
wiley +1 more source
Time series aerial photographs to detect spatio-temporal changes in coastal areas of Fiji [PDF]
The South Pacific Journal of Natural and Applied Sciences, 2008 Gennady Gienko +2 more
openaire +1 more source
A Cryopreservation‐Based Supply Chain Strategy for Extrusion Bioprinting in Space
Advanced Materials Technologies, EarlyView.Extrusion bioprinting on crewed space platforms requires a bioink that stays functional along the logistic chain. Here, cells and biomaterial ink travel separately, the cells cryopreserved and the ink cold stored, and are combined only minutes before printing.
Johannes Windisch +7 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti +4 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.Desktop vacuum thermoforming enables rapid, low‐cost fabrication of 96‐channel polystyrene culture chips with very thin imaging interfaces. The resulting platform supports cell lines, primary cells, and patient‐derived organoids, and enables high‐resolution confocal microscopy and single‐cell visualization, providing an accessible approach for advanced
Aleksandra Fomina +5 more
wiley +1 more source
Light‐Driven Quadrupedal Walking Biohybrid Robot With Antagonistic Muscle‐Rings and Inclined Joints
Advanced Robotics Research, EarlyView.This work presents a light‐driven quadrupedal walking biohybrid robot powered by antagonistic muscle‐rings that achieve alternating walking gait. Optical training improved reproducibility of cultured muscle tissues, while caffeine treatment enhanced contractile force.
Shotaro Saito +5 more
wiley +1 more source
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source