Results 171 to 180 of about 73,656 (257)

Machine Learning of Temperature‐Dependent Chemical Kinetics Using Parallel Droplet Microreactors

Advanced Science, EarlyView.
An integrated droplet microfluidics and machine learning framework enables high‐throughput characterization of temperature‐dependent reaction kinetics. Time‐resolved measurements from thousands of droplets train Neural ODE models that accurately predict nonlinear reaction dynamics across diverse thermal environments, bridging large‐scale ...
Mamoru Saita, Yutaka Hori
wiley   +1 more source

Optimized protocol for live imaging of Bacillus subtilis phage infection at a single-cell resolution. [PDF]

STAR Protoc
Bonham HR, Grosboillot V, Floccari VA, Dogša I, Dragoš A.   +4 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Shape factor analysis as a quantitative framework for assessing spheroid and organoid morphology and invasiveness. [PDF]

APL Bioeng
Schutrum BE, Deng J, Kim JH, Gao A, Hur E, Crowley JC, Ling L, Pirtz MG, Ralston CQ, Nikitin AY, Fischbach C.   +10 more
europepmc   +1 more source

Between Two Truths: Time in Physics and Fiji

Social Analysis, 2017
openaire   +1 more source

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

Lifestyle interventions for obesity prevention among adolescents in Pacific Islands Countries and Territories: a narrative review of outcomes and sociocultural, spatial and temporal dimensions. [PDF]

Lancet Reg Health West Pac
Galy O, Urvoy MJ, Bertrand S, Caillaud C, Bay J, Frayon S, Wattelez G, Allman-Farinelli M, Raubenheimer D, Novotny R, Okely A.   +10 more
europepmc   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

High-Content Immunofluorescence Quantification of Transcription Factors: Application to pSMADs for BMP/TGFβ Signaling Pathways. [PDF]

Curr Protoc
Khodr V, Machillot P, Picart C.
europepmc   +1 more source

Inverse Design of Pre‐Strain via a Predictive Electromechanical Model for Enhanced Strain Sensing

Advanced Science, EarlyView.
An analytical electromechanical model rooted in microcrack evolution mechanics is globally calibrated from only eight pre‐strain datasets, enabling prediction of the complete sensing response at untested pre‐strain values within the calibrated design space (R2 > 0.99).
Jia‐Chen Shang, Rui Wang, Bo Lu, Ming‐Liang Song, Yu‐Yi Chen, Kuo Han, Xin‐Jie Feng, Bin Sun, Yao‐Guang Cao, Xiao‐Yu Yan, Shi‐Chun Yang   +10 more
wiley   +1 more source