Results 131 to 140 of about 2,323,981 (293)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
\u3cem\u3eThe Cherry Beret\u3c/em\u3e by Ashton L. Kerr [Review] [PDF]
, 2012 Review of Colonel Ashton L. Kerr, MD, The Cherry Beret: Distant recollections of World War II as remembered by one of the first Canloan officers.
Martin, Markus C.
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Neurasthenia, Robert Graves, and Poetic Therapy in the Great War [PDF]
, 2017 Though Robert Graves is remembered primarily for his memoir, Good-bye to All That, his First World War poetry is equally relevant. Comparably to the more famous writings of Sassoon and Owen, Graves\u27 war poems depict the trauma of the trenches, marked ...
Sebock, Juliette E.
core +1 more source
Reforming the veteran: propaganda and agency in the First World War Reconstruction hospitals. [PDF]
J Med Libr Assoc, 2019 Jackson A.
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
From Enlistment to the Grave: The Impact of the First World War on 52 Canadian Soldiers [PDF]
, 2012 Because they have clearly demarcated beginnings and endings, wars tend to be studied in isolation. Studies are made of the events leading up to wars, the wars themselves, and their aftermaths as though each could be easily pigeon-holed.
Wert, Mike
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source