Results 61 to 70 of about 13,349 (267)

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

open access: yesAdvanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao   +5 more
wiley   +1 more source

East meets West

open access: yesActa Periodica Duellatorum, 2017
By the Late Middle Ages, mounted troops - cavalry in the form of knights - are established as the dominant battlefield arm in North-Western Europe. This paper considers the development of cavalry after the Germanic Barbarian Successor Kingdoms such as ...
Jürg Gassmann
doaj   +1 more source

Chemically Gradient Ordered Nanodomains Enable Large Tensile Ductility in Gigapascal Lightweight Refractory High‐Entropy Alloys

open access: yesAdvanced Science, EarlyView.
A high‐strength lightweight refractory high‐entropy alloy achieves extraordinary ductility owing to the introduction of coherent chemically gradient ordered nanodomains (CGONs). The CGONs not only serve as effective barriers to dislocation motion (strengthening) but also significantly promote dislocation nucleation and multiplication (ductilizing) upon
Wei Zhang   +3 more
wiley   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

open access: yesAdvanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai   +9 more
wiley   +1 more source

Shooting Experiments with Early Medieval Arrowheads

open access: yesEXARC Journal, 2019
In the Merovingian era (5th-8th century AD) a lot of variously shaped iron arrowheads were used by the Franks, Alemannians and Bavarians, who dwelled in the region known today as Germany, Austria and Switzerland (See Figure 1).
Holger Riesch
doaj  

The history of Andulus during the Islamic Era and the Rule of Arabs (711 - 755 A.D) [PDF]

open access: yesتاریخ اسلام, 2000
After capturing Maghreb, Moslems sought for more conquests in order to make the field ready to spread Islam more and more. The Moslems' readiness and appropriate circumstances prepared the arrangements for the spread of Islam in a vast area, called ...
gholamreza jamshid-nezhad avval
doaj  

Wafer‐Scale Atomically‐Thin Gold: Transferable Platform for Flexible Optoelectronics, Thermal Management and Bio‐Interfaces

open access: yesAdvanced Science, EarlyView.
Combining template stripping with a graphene‐inspired transfer yields continuous, transferable gold films at 6‐inch wafer scale with thicknesses approaching the atomic limit. The atomically smooth, near‐bulk‐quality films offer above 86% transmittance and sub‐20 Ω/square sheet resistance, serving as a universal platform for flexible optoelectronics ...
Dmitry Yakubovsky   +24 more
wiley   +1 more source

Gap‐Free Information Transfer in 4D‐STEM via Fusion of Complementary Scattering Channels

open access: yesAdvanced Science, EarlyView.
Fused Full‐Field STEM (FF‐STEM) is introduced as a 4D‐STEM imaging modality that combines direct ptychography with tilt‐corrected dark‐field reconstruction in a single acquisition. Fourier‐space fusion using Wiener‐type spectral weighting closes the low‐frequency contrast gap inherent to bright‐field methods, delivering gap‐free, dose‐efficient, near ...
Shengbo You   +15 more
wiley   +1 more source

East meets West: Mounted Encounters in Early and High Mediaeval Europe

open access: yesActa Periodica Duellatorum, 2017
By the Late Middle Ages, mounted troops - cavalry in the form of knights - are established as the dominant battlefield arm in North-Western Europe. This paper considers the development of cavalry after the Germanic Barbarian Successor Kingdoms such as ...
Gassmann Jürg
doaj   +1 more source

Ductile B2 Intermetallics‐Driven Strength‐Ductility Synergy in Heterolaminated Multi‐Principal Element Alloys

open access: yesAdvanced Science, EarlyView.
Intrinsic phase toughening transforms a brittle B2 intermetallic into a plastically deformable, load‐bearing phase, while a heterogeneous laminated architecture suppresses strain localization and interface cracking. The synergy between ductile intermetallics and mesoscale heterogeneity establishes a general design strategy for breaking the long ...
Lu Yang   +9 more
wiley   +1 more source

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