Results 171 to 180 of about 128,360,030 (297)

Functioning first: Rethinking physical therapy through its core construct. [PDF]

Braz J Phys Ther
Jorge CH, Oliveira VC, De Campos AC.
europepmc   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Non-coding RNAs and Mitochondrial Dysfunction in Alzheimer's Disease: A Systematic Review. [PDF]

Mol Neurobiol
Mocrei-Rebrean ȘM, Răzniceanu V, Pintilie SR, Berindan-Neagoe I.   +3 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Emerging themes and technologies in multi-organismal approaches to understanding mycorrhizal functioning. [PDF]

J Exp Bot
Johnson D, Weremijewicz J, Wanke A.
europepmc   +1 more source

Forward frontal fields: phylogeny and fundamental function. [PDF]

Trends Neurosci, 2008
Wise SP.
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Stomata: an introduction to a Virtual Issue. [PDF]

New Phytol
Assmann SM, Dong J, Gray JE, Hõrak H, Liang YK, Song CP, Yang S, Hetherington AM.   +7 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Fundamental limits incorporating logical reasoning into Shannon's information theory. [PDF]

Proc Natl Acad Sci U S A
Lastras LA, Lenchner J, Trager BM, Szpankowski W, Squillante MS, Wu CW, Fagin R, Gray A.   +7 more
europepmc   +1 more source