Results 231 to 240 of about 128,360,030 (297)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Surface chiral Abelian topological order on multilayer cluster Mott insulators. [PDF]

PNAS Nexus
Yao XP, Li CK, Chen GV.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An IR-RIME-SQP-Based Spectrum Modification Method for Shallow Surface Electromagnetic Detection Transmitting Scheme of Metal Traps in Forested Areas. [PDF]

Sensors (Basel)
An Z, Fan X, Wang Y, Zhang T.
europepmc   +1 more source

One-Cycle Windowed-DFT Harmonic Estimation with Spectral-Interference Compensation. [PDF]

Sensors (Basel)
Allioua C, Mingotti A, Tinarelli R, Peretto L.   +3 more
europepmc   +1 more source

Cardiac regulatory mechanisms: Translating fundamental discoveries into novel therapeutics. [PDF]

J Physiol
Do TQ, Knollmann BC.
europepmc   +1 more source

Fundamental Movement Skills in Children and Adolescents-Bridging the Gap Between Theory and Practice. [PDF]

Children (Basel)
Gąsior JS.
europepmc   +1 more source

Spectra: Tokens of the Physical WorldA Unifying Framework for Encoding, Connection, Interpretation, and Generation. [PDF]

Precis Chem
Luo Y.
europepmc   +1 more source

Nanoworld of terahertz magnetism opening new frontiers.

Newton
Kimel AV, Ivanov BA, Afanasiev D.
europepmc   +1 more source