Can digital self-screening improve identification of chronic dyspnoea in Australian general practice? A proof-of-concept protocol for the BREATHE SMART trial. [PDF]
BMJ OpenJang K +7 more
europepmc +1 more source
Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants
Advanced Science, EarlyView.The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann +11 more
wiley +1 more source
Implementing the Virtual Integrated Practice (VIP) Program to Support Rural General Practice Viability in Australia. [PDF]
Aust J Rural HealthJob J, Strauss R, Martin Z, Jackson C.
europepmc +1 more source
Hydrothermal Embedding of Pd Single Atoms Into SnO2 for Efficient CO Oxidation
Advanced Science, EarlyView.By applying hydrothermal regulation to SnO2‐supported PdO, we achieve atomic dispersion of Pd into the SnO2 lattice, which activates the lattice oxygen neighboring Pd atoms to generate oxygen vacancies and facilitates subsequent O2 activation, thereby promoting CO oxidation to proceed via a low‐energy‐barrier MvK pathway while avoiding CO poisoning ...
Yingsheng An +12 more
wiley +1 more source
The Regional Implementation of an Electronic Health Record-Integrated Ambient Scribe in Primary and Secondary Care in England: Real-Time Qualitative Evaluation. [PDF]
JMIR Med InformCresswell K +4 more
europepmc +1 more source
Advanced Science, EarlyView.This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang +10 more
wiley +1 more source
Use of failure mode and effects analysis for risk analysis of investigational drug products management in clinical trials. [PDF]
Am J Health Syst PharmZhang B, Song M, Wang Z, Zhou Y, Pang X.
europepmc +1 more source
Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
Advanced Science, EarlyView.MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
The GRACE video-telehealth project protocol: a mixed-methods study to improve quality, safety and acceptability of video-telehealth in Australian general practice and residential aged care. [PDF]
BMJ OpenCarrigan A +22 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen +7 more
wiley +1 more source